Characterization of individuals at high risk of developing melanoma in Latin America: bases for genetic counseling in melanoma

CDKN2A is the main high-risk melanoma-susceptibility gene, but it has been poorly assessed in Latin America. We sought to analyze CDKN2A and MC1R in patients from Latin America with familial and sporadic multiple primary melanoma (SMP) and compare the data with those for patients from Spain to estab...

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Veröffentlicht in:	Genetics in medicine 2016-07, Vol.18 (7), p.727-736
Hauptverfasser:	Puig, Susana, Potrony, Miriam, Cuellar, Francisco, Puig-Butille, Joan Anton, Carrera, Cristina, Aguilera, Paula, Nagore, Eduardo, Garcia-Casado, Zaida, Requena, Celia, Kumar, Rajiv, Landman, Gilles, Costa Soares de Sá, Bianca, Gargantini Rezze, Gisele, Facure, Luciana, de Avila, Alexandre Leon Ribeiro, Achatz, Maria Isabel, Carraro, Dirce Maria, Duprat Neto, João Pedreira, Grazziotin, Thais C., Bonamigo, Renan R., Rey, Maria Carolina W., Balestrini, Claudia, Morales, Enrique, Molgo, Montserrat, Bakos, Renato Marchiori, Ashton-Prolla, Patricia, Giugliani, Roberto, Larre Borges, Alejandra, Barquet, Virginia, Pérez, Javiera, Martínez, Miguel, Cabo, Horacio, Cohen Sabban, Emilia, Latorre, Clara, Carlos-Ortega, Blanca, Salas-Alanis, Julio C, Gonzalez, Roger, Olazaran, Zulema, Malvehy, Josep, Badenas, Celia
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/68 692/699/67/1813/1634 692/700/228/2050/1510 692/700/478/174 Adult Aged Biomedicine CDKN2A Cyclin-Dependent Kinase Inhibitor p16 Cyclin-Dependent Kinase Inhibitor p18 - genetics familial Female Genetic Counseling Genetic Predisposition to Disease Germ-Line Mutation Human Genetics Humans Laboratory Medicine Latin America Male MC1R melanoma Melanoma - diagnosis Melanoma - epidemiology Melanoma - genetics Melanoma - pathology Middle Aged Original original-research-article Receptor, Melanocortin, Type 1 - genetics Risk Factors Spain
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