Cyclooxygenase inhibition targets neurons to prevent early behavioural decline in Alzheimer's disease model mice

Identifying preventive targets for Alzheimer's disease is a central challenge of modern medicine. Non-steroidal anti-inflammatory drugs, which inhibit the cyclooxygenase enzymes COX-1 and COX-2, reduce the risk of developing Alzheimer's disease in normal ageing populations. This preventive...

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Veröffentlicht in:	Brain (London, England : 1878) England : 1878), 2016-07, Vol.139 (Pt 7), p.2063-2081
Hauptverfasser:	Woodling, Nathaniel S, Colas, Damien, Wang, Qian, Minhas, Paras, Panchal, Maharshi, Liang, Xibin, Mhatre, Siddhita D, Brown, Holden, Ko, Novie, Zagol-Ikapitte, Irene, van der Hart, Marieke, Khroyan, Taline V, Chuluun, Bayarsaikhan, Priyam, Prachi G, Milne, Ginger L, Rassoulpour, Arash, Boutaud, Olivier, Manning-Boğ, Amy B, Heller, H Craig, Andreasson, Katrin I
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - prevention & control Animals Behavior, Animal - drug effects Cyclooxygenase Inhibitors Disease Models, Animal Down-Regulation Editor's Choice Electroencephalography Gene Expression - drug effects Hippocampus - drug effects Ibuprofen Male Memory Disorders - prevention & control Mice Mice, Inbred C57BL Neuronal Plasticity - drug effects Neurons - drug effects Original Rats Recognition (Psychology) - drug effects Signal Transduction - drug effects Tryptophan Oxygenase - drug effects
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