A combinatorial strategy for treating KRAS-mutant lung cancer

Therapeutic targeting of KRAS-mutant lung adenocarcinoma represents a major goal of clinical oncology. KRAS itself has proved difficult to inhibit, and the effectiveness of agents that target key KRAS effectors has been thwarted by activation of compensatory or parallel pathways that limit their eff...

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Veröffentlicht in:	Nature (London) 2016-06, Vol.534 (7609), p.647-651
Hauptverfasser:	Manchado, Eusebio, Weissmueller, Susann, Morris, John P., Chen, Chi-Chao, Wullenkord, Ramona, Lujambio, Amaia, de Stanchina, Elisa, Poirier, John T., Gainor, Justin F., Corcoran, Ryan B., Engelman, Jeffrey A., Rudin, Charles M., Rosen, Neal, Lowe, Scott W.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/89 631/67/1059 631/67/1612 64/110 64/60 Adenocarcinoma Adenocarcinoma - drug therapy Adenocarcinoma - genetics Adenocarcinoma - pathology Adenocarcinoma of Lung Animals Antineoplastic Combined Chemotherapy Protocols Cancer cells Care and treatment Cell death Cell Death - drug effects Cell Proliferation - drug effects Chemotherapy Colonic Neoplasms - genetics Colonic Neoplasms - pathology Disease Models, Animal Drug resistance Drug Resistance, Neoplasm Drug Screening Assays, Antitumor Enzyme Activation - drug effects Feedback, Physiological Female Genetic aspects Humanities and Social Sciences Humans Imidazoles - pharmacology Imidazoles - therapeutic use Inhibitor drugs Lung cancer Lung Neoplasms - drug therapy Lung Neoplasms - genetics Lung Neoplasms - pathology MAP Kinase Signaling System - drug effects Medical research Medicine, Experimental Methods Mice Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors Molecular targeted therapy multidisciplinary Mutant Proteins - genetics Mutants Mutation Pancreatic cancer Pancreatic Neoplasms - genetics Pancreatic Neoplasms - pathology Phosphorylation Phosphorylation - drug effects Proto-Oncogene Proteins p21(ras) - genetics Pyridazines - pharmacology Pyridazines - therapeutic use Pyridones - pharmacology Pyridones - therapeutic use Pyrimidinones - pharmacology Pyrimidinones - therapeutic use Receptor, Fibroblast Growth Factor, Type 1 - antagonists & inhibitors Receptor, Fibroblast Growth Factor, Type 1 - metabolism Science Tumors Xenograft Model Antitumor Assays
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