Adolescent BMI Trajectory and Risk of Diabetes versus Coronary Disease
This study followed healthy young men, with repeated measures of height and weight over a mean of 17.4 years. Elevated BMI in adolescence, even within the normal range, was found to be a substantial risk factor for later obesity-related disorders, including type 2 diabetes and CHD. Although obesity...
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| Veröffentlicht in: | The New England journal of medicine 2011-04, Vol.364 (14), p.1315-1325 |
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| container_title | The New England journal of medicine |
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| creator | Tirosh, Amir Shai, Iris Afek, Arnon Dubnov-Raz, Gal Ayalon, Nir Gordon, Barak Derazne, Estela Tzur, Dorit M.D, Ari Shamis Vinker, Shlomo Rudich, Assaf |
| description | This study followed healthy young men, with repeated measures of height and weight over a mean of 17.4 years. Elevated BMI in adolescence, even within the normal range, was found to be a substantial risk factor for later obesity-related disorders, including type 2 diabetes and CHD.
Although obesity in adulthood is a well-documented risk factor for both type 2 diabetes and coronary heart disease, it remains unclear whether a longer history of relative overweight, starting earlier in life, poses an additional risk. Furthermore, whereas the trajectory of weight and height from birth to adolescence is well documented, the progression of body-mass index (BMI) from adolescence into adulthood is less well described. Obese children probably have higher odds of becoming obese adults.
1
Moreover, although an elevated BMI in childhood or adolescence may not necessarily represent adiposity,
2
–
4
childhood obesity is associated with classic cardiometabolic risk factors, as . . . |
| doi_str_mv | 10.1056/NEJMoa1006992 |
| format | Article |
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Although obesity in adulthood is a well-documented risk factor for both type 2 diabetes and coronary heart disease, it remains unclear whether a longer history of relative overweight, starting earlier in life, poses an additional risk. Furthermore, whereas the trajectory of weight and height from birth to adolescence is well documented, the progression of body-mass index (BMI) from adolescence into adulthood is less well described. Obese children probably have higher odds of becoming obese adults.
1
Moreover, although an elevated BMI in childhood or adolescence may not necessarily represent adiposity,
2
–
4
childhood obesity is associated with classic cardiometabolic risk factors, as . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMoa1006992</identifier><identifier>PMID: 21470009</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Waltham, MA: Massachusetts Medical Society</publisher><subject>Adolescent ; Adult ; Age ; Biological and medical sciences ; Blood Glucose - analysis ; Body Mass Index ; Cardiology. Vascular system ; Cardiovascular disease ; Child development ; Coronary Disease - epidemiology ; Coronary heart disease ; Diabetes ; Diabetes Mellitus, Type 2 - epidemiology ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; General aspects ; Heart ; Humans ; Incidence ; Linear Models ; Male ; Medical sciences ; Multivariate Analysis ; Obesity ; Obesity - complications ; Prospective Studies ; Risk</subject><ispartof>The New England journal of medicine, 2011-04, Vol.364 (14), p.1315-1325</ispartof><rights>Copyright © 2011 Massachusetts Medical Society. All rights reserved.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c473t-7f846b69e37d0182c7c4f2792431b69969ec6adc9a4e3e027fa66321580bc2c13</citedby><cites>FETCH-LOGICAL-c473t-7f846b69e37d0182c7c4f2792431b69969ec6adc9a4e3e027fa66321580bc2c13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMoa1006992$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJMoa1006992$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>230,314,776,780,881,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24042699$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21470009$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tirosh, Amir</creatorcontrib><creatorcontrib>Shai, Iris</creatorcontrib><creatorcontrib>Afek, Arnon</creatorcontrib><creatorcontrib>Dubnov-Raz, Gal</creatorcontrib><creatorcontrib>Ayalon, Nir</creatorcontrib><creatorcontrib>Gordon, Barak</creatorcontrib><creatorcontrib>Derazne, Estela</creatorcontrib><creatorcontrib>Tzur, Dorit</creatorcontrib><creatorcontrib>M.D, Ari Shamis</creatorcontrib><creatorcontrib>Vinker, Shlomo</creatorcontrib><creatorcontrib>Rudich, Assaf</creatorcontrib><title>Adolescent BMI Trajectory and Risk of Diabetes versus Coronary Disease</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>This study followed healthy young men, with repeated measures of height and weight over a mean of 17.4 years. Elevated BMI in adolescence, even within the normal range, was found to be a substantial risk factor for later obesity-related disorders, including type 2 diabetes and CHD.
Although obesity in adulthood is a well-documented risk factor for both type 2 diabetes and coronary heart disease, it remains unclear whether a longer history of relative overweight, starting earlier in life, poses an additional risk. Furthermore, whereas the trajectory of weight and height from birth to adolescence is well documented, the progression of body-mass index (BMI) from adolescence into adulthood is less well described. Obese children probably have higher odds of becoming obese adults.
1
Moreover, although an elevated BMI in childhood or adolescence may not necessarily represent adiposity,
2
–
4
childhood obesity is associated with classic cardiometabolic risk factors, as . . .</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - analysis</subject><subject>Body Mass Index</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular disease</subject><subject>Child development</subject><subject>Coronary Disease - epidemiology</subject><subject>Coronary heart disease</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 2 - epidemiology</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>General aspects</subject><subject>Heart</subject><subject>Humans</subject><subject>Incidence</subject><subject>Linear Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Multivariate Analysis</subject><subject>Obesity</subject><subject>Obesity - complications</subject><subject>Prospective Studies</subject><subject>Risk</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kUtLxDAUhYMoOo4u3UoRxFU1r0mbjaDjGx8gug6Z9FY7to3mtoL_3gyOTzCbkNyPc8_hELLB6C6jI7V3fXxx5S2jVGnNF8iAjYRIpaRqkQwo5XkqMy1WyCrilMbDpF4mK5zJLD70gJwcFL4GdNB2yeHVeXIX7BRc58NbYtsiua3wKfFlclTZCXSAySsE7DEZ--BbG6GjCsEirJGl0tYI6_N7SO5Pju_GZ-nlzen5-OAydTITXZqVuVQTpUFkBWU5d5mTJc80l4LFbx0nTtnCaStBAOVZaZUSnI1yOnHcMTEk-x-6z_2kgWJmO9jaPIeqiW6Mt5X5PWmrR_PgX43UQvORjgI7c4HgX3rAzjRVTF_XtgXfo8kV41TKfLZq6w859X1oY7oI5dGWiJGGJP2AXPCIAcovK4yaWT_mVz-R3_zp_4v-LCQC23PAorN1GWzrKvzmJJU8Kn1zTYOmhWnzz8J3Zniikg</recordid><startdate>20110407</startdate><enddate>20110407</enddate><creator>Tirosh, Amir</creator><creator>Shai, Iris</creator><creator>Afek, Arnon</creator><creator>Dubnov-Raz, Gal</creator><creator>Ayalon, Nir</creator><creator>Gordon, Barak</creator><creator>Derazne, Estela</creator><creator>Tzur, Dorit</creator><creator>M.D, Ari Shamis</creator><creator>Vinker, Shlomo</creator><creator>Rudich, Assaf</creator><general>Massachusetts Medical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20110407</creationdate><title>Adolescent BMI Trajectory and Risk of Diabetes versus Coronary Disease</title><author>Tirosh, Amir ; Shai, Iris ; Afek, Arnon ; Dubnov-Raz, Gal ; Ayalon, Nir ; Gordon, Barak ; Derazne, Estela ; Tzur, Dorit ; M.D, Ari Shamis ; Vinker, Shlomo ; Rudich, Assaf</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c473t-7f846b69e37d0182c7c4f2792431b69969ec6adc9a4e3e027fa66321580bc2c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - analysis</topic><topic>Body Mass Index</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular disease</topic><topic>Child development</topic><topic>Coronary Disease - epidemiology</topic><topic>Coronary heart disease</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 2 - epidemiology</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>General aspects</topic><topic>Heart</topic><topic>Humans</topic><topic>Incidence</topic><topic>Linear Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Multivariate Analysis</topic><topic>Obesity</topic><topic>Obesity - complications</topic><topic>Prospective Studies</topic><topic>Risk</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tirosh, Amir</creatorcontrib><creatorcontrib>Shai, Iris</creatorcontrib><creatorcontrib>Afek, Arnon</creatorcontrib><creatorcontrib>Dubnov-Raz, Gal</creatorcontrib><creatorcontrib>Ayalon, Nir</creatorcontrib><creatorcontrib>Gordon, Barak</creatorcontrib><creatorcontrib>Derazne, Estela</creatorcontrib><creatorcontrib>Tzur, Dorit</creatorcontrib><creatorcontrib>M.D, Ari Shamis</creatorcontrib><creatorcontrib>Vinker, Shlomo</creatorcontrib><creatorcontrib>Rudich, Assaf</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tirosh, Amir</au><au>Shai, Iris</au><au>Afek, Arnon</au><au>Dubnov-Raz, Gal</au><au>Ayalon, Nir</au><au>Gordon, Barak</au><au>Derazne, Estela</au><au>Tzur, Dorit</au><au>M.D, Ari Shamis</au><au>Vinker, Shlomo</au><au>Rudich, Assaf</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adolescent BMI Trajectory and Risk of Diabetes versus Coronary Disease</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>2011-04-07</date><risdate>2011</risdate><volume>364</volume><issue>14</issue><spage>1315</spage><epage>1325</epage><pages>1315-1325</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><coden>NEJMAG</coden><abstract>This study followed healthy young men, with repeated measures of height and weight over a mean of 17.4 years. Elevated BMI in adolescence, even within the normal range, was found to be a substantial risk factor for later obesity-related disorders, including type 2 diabetes and CHD.
Although obesity in adulthood is a well-documented risk factor for both type 2 diabetes and coronary heart disease, it remains unclear whether a longer history of relative overweight, starting earlier in life, poses an additional risk. Furthermore, whereas the trajectory of weight and height from birth to adolescence is well documented, the progression of body-mass index (BMI) from adolescence into adulthood is less well described. Obese children probably have higher odds of becoming obese adults.
1
Moreover, although an elevated BMI in childhood or adolescence may not necessarily represent adiposity,
2
–
4
childhood obesity is associated with classic cardiometabolic risk factors, as . . .</abstract><cop>Waltham, MA</cop><pub>Massachusetts Medical Society</pub><pmid>21470009</pmid><doi>10.1056/NEJMoa1006992</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The New England journal of medicine, 2011-04, Vol.364 (14), p.1315-1325 |
| issn | 0028-4793 1533-4406 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; New England Journal of Medicine |
| subjects | Adolescent Adult Age Biological and medical sciences Blood Glucose - analysis Body Mass Index Cardiology. Vascular system Cardiovascular disease Child development Coronary Disease - epidemiology Coronary heart disease Diabetes Diabetes Mellitus, Type 2 - epidemiology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance General aspects Heart Humans Incidence Linear Models Male Medical sciences Multivariate Analysis Obesity Obesity - complications Prospective Studies Risk |
| title | Adolescent BMI Trajectory and Risk of Diabetes versus Coronary Disease |
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