Chronic Cognitive Dysfunction after Traumatic Brain Injury Is Improved with a Phosphodiesterase 4B Inhibitor

Learning and memory impairments are common in traumatic brain injury (TBI) survivors. However, there are no effective treatments to improve TBI-induced learning and memory impairments. TBI results in decreased cAMP signaling and reduced cAMP-response-element binding protein (CREB) activation, a crit...

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Veröffentlicht in:	The Journal of neuroscience 2016-07, Vol.36 (27), p.7095-7108
Hauptverfasser:	Titus, David J, Wilson, Nicole M, Freund, Julie E, Carballosa, Melissa M, Sikah, Kevin E, Furones, Concepcion, Dietrich, W Dalton, Gurney, Mark E, Atkins, Coleen M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain Injuries, Traumatic - complications Cognition Disorders - drug therapy Cognition Disorders - etiology Conditioning, Classical - drug effects Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism Disease Models, Animal Fear - drug effects Hippocampus - drug effects Hippocampus - physiology Interleukin-1beta - metabolism Long-Term Potentiation - drug effects Male Maze Learning - drug effects Memory, Short-Term - drug effects Nerve Tissue Proteins - metabolism Phenylacetates - pharmacology Phenylacetates - therapeutic use Phosphodiesterase 4 Inhibitors - therapeutic use Rats Rats, Sprague-Dawley Reaction Time - drug effects Thiophenes - pharmacology Thiophenes - therapeutic use Tumor Necrosis Factor-alpha - metabolism
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