Selective Deletion of Astroglial FMRP Dysregulates Glutamate Transporter GLT1 and Contributes to Fragile X Syndrome Phenotypes In Vivo

How the loss of fragile X mental retardation protein (FMRP) in different brain cell types, especially in non-neuron glial cells, induces fragile X syndrome (FXS) phenotypes has just begun to be understood. In the current study, we generated inducible astrocyte-specific Fmr1 conditional knock-out mic...

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Veröffentlicht in:	The Journal of neuroscience 2016-07, Vol.36 (27), p.7079-7094
Hauptverfasser:	Higashimori, Haruki, Schin, Christina S, Chiang, Ming Sum R, Morel, Lydie, Shoneye, Temitope A, Nelson, David L, Yang, Yongjie
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - genetics Age Factors Animals Animals, Newborn Astrocytes - metabolism Astrocytes - ultrastructure Cerebral Cortex - pathology Disease Models, Animal Estrogen Antagonists - pharmacology Excitatory Amino Acid Transporter 2 - genetics Excitatory Amino Acid Transporter 2 - metabolism Fragile X Mental Retardation Protein - genetics Fragile X Mental Retardation Protein - metabolism Fragile X Syndrome - genetics Fragile X Syndrome - metabolism Fragile X Syndrome - pathology Gene Expression Regulation - drug effects Gene Expression Regulation - genetics In Vitro Techniques Mice Mice, Inbred C57BL Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Pyramidal Cells - drug effects Pyramidal Cells - physiology Tamoxifen - pharmacology Transcription Factors - genetics Transcription Factors - metabolism
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