Defining the Essential Function of Yeast Hsf1 Reveals a Compact Transcriptional Program for Maintaining Eukaryotic Proteostasis

Despite its eponymous association with the heat shock response, yeast heat shock factor 1 (Hsf1) is essential even at low temperatures. Here we show that engineered nuclear export of Hsf1 results in cytotoxicity associated with massive protein aggregation. Genome-wide analysis revealed that Hsf1 nuc...

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Veröffentlicht in:	Molecular cell 2016-07, Vol.63 (1), p.60-71
Hauptverfasser:	Solís, Eric J., Pandey, Jai P., Zheng, Xu, Jin, Dexter X., Gupta, Piyush B., Airoldi, Edoardo M., Pincus, David, Denic, Vladimir
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals carcinogenesis cell growth Cell Line CRISPR-Cas Systems cytotoxicity DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Embryonic Stem Cells - metabolism Fibroblasts - metabolism gene expression Gene Expression Regulation, Fungal gene induction Gene Regulatory Networks genes heat shock proteins Heat Shock Transcription Factors Heat-Shock Proteins - genetics Heat-Shock Proteins - metabolism Heat-Shock Response Homeostasis HSP70 Heat-Shock Proteins - metabolism HSP90 Heat-Shock Proteins - metabolism mammals messenger RNA Mice, 129 Strain Mice, Inbred CBA physiological transport Protein Aggregates Protein Interaction Maps RNA, Fungal - genetics RNA, Fungal - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism temperature Time Factors transcription (genetics) Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic Transfection yeasts
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