Mechanism of High-Frequency Signaling at a Depressing Ribbon Synapse

Ribbon synapses mediate continuous release in neurons that have graded voltage responses. While mammalian retinas can signal visual flicker at 80–100 Hz, the time constant, τ, for the refilling of a depleted vesicle release pool at cone photoreceptor ribbons is 0.7–1.1 s. Due to this prolonged depre...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2016-07, Vol.91 (1), p.133-145
Hauptverfasser:	Grabner, Chad P., Ratliff, Charles P., Light, Adam C., DeVries, Steven H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium - metabolism Electric Stimulation - methods Excitatory Postsynaptic Potentials - physiology Exocytosis - physiology Light Monte Carlo simulation Retina - physiology Retinal Bipolar Cells - metabolism Retinal Cone Photoreceptor Cells - metabolism Rodents Signal Transduction - physiology Synapses - physiology Synaptic Transmission - physiology
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