Assembly of eIF3 Mediated by Mutually Dependent Subunit Insertion

Eukaryotic initiation factor 3 (eIF3), an essential multi-protein complex involved in translation initiation, is composed of 12 tightly associated subunits in humans. While the overall structure of eIF3 is known, the mechanism of its assembly and structural consequences of dysregulation of eIF3 subu...

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Veröffentlicht in:	Structure (London) 2016-06, Vol.24 (6), p.886-896
Hauptverfasser:	Smith, M. Duane, Arake-Tacca, Luisa, Nitido, Adam, Montabana, Elizabeth, Park, Annsea, Cate, Jamie H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Eukaryotic Initiation Factor-3 - chemistry Eukaryotic Initiation Factor-3 - metabolism Fungal Proteins - chemistry Fungal Proteins - metabolism Gene Expression Regulation Humans Models, Molecular Neurospora crassa - chemistry Neurospora crassa - metabolism Protein Binding Protein Domains Protein Multimerization Protein Structure, Secondary
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