CpsR, a GntR family regulator, transcriptionally regulates capsular polysaccharide biosynthesis and governs bacterial virulence in Streptococcus pneumoniae

Transcriptional regulation of capsule expression is critical for pneumococcal transition from carriage to infection, yet the underlying mechanism remains incompletely understood. Here, we describe the regulation of capsular polysaccharide, one of the most important pneumococcal virulence factor by a...

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Veröffentlicht in:	Scientific reports 2016-07, Vol.6 (1), p.29255-29255, Article 29255
Hauptverfasser:	Wu, Kaifeng, Xu, Hongmei, Zheng, Yuqiang, Wang, Libin, Zhang, Xuemei, Yin, Yibing
Format:	Artikel
Sprache:	eng
Schlagworte:	42 42/41 45/77 631/326/1320 631/337/572/2102 64 82/80 Animals Bacterial Proteins - genetics Bacterial Proteins - metabolism Binding Sites Biosynthesis Blood Bactericidal Activity Chromatography DNA Footprinting DNA, Bacterial - metabolism Electrophoretic Mobility Shift Assay Gene Deletion Gene Expression Regulation, Bacterial Genes Genetic Complementation Test Humanities and Social Sciences Mass spectrometry Mice, Inbred BALB C multidisciplinary Pathogenesis Pathogens Pneumococcal Infections - microbiology Pneumococcal Infections - pathology Polysaccharides, Bacterial - biosynthesis Promoter Regions, Genetic Protein Binding Proteins Science Science (multidisciplinary) Scientific imaging Streptococcus infections Streptococcus pneumoniae - genetics Streptococcus pneumoniae - metabolism Streptococcus pneumoniae - pathogenicity Survival Analysis Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic Virulence
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