Maternal betaine supplementation during gestation modifies hippocampal expression of GR and its regulatory miRNAs in neonatal piglets

Methyl donor nutrients are critical for embryonic development of brain. Hippocampus is the most susceptible brain region to various factors including prenatal supply of methyl donors. Glucocorticoid receptor (GR) expressed in hippocampus is involved in the regulation of energy homeostasis and stress...

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Veröffentlicht in:	Journal of Veterinary Medical Science 2016, Vol.78(6), pp.921-928
Hauptverfasser:	SUN, Qinwei, LI, Xi, JIA, Yimin, PAN, Shifeng, LI, Runsheng, YANG, Xiaojing, ZHAO, Ruqian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn - metabolism betaine Betaine - pharmacology Dietary Supplements Female Gene Expression Regulation, Developmental - drug effects glucocorticoid receptor hippocampus Hippocampus - drug effects Hippocampus - metabolism Hippocampus - physiology methylation MicroRNAs - biosynthesis MicroRNAs - physiology miRNA Physiology Pregnancy Prenatal Exposure Delayed Effects - metabolism Real-Time Polymerase Chain Reaction Receptors, Glucocorticoid - metabolism Receptors, Glucocorticoid - physiology Swine
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