Stilbenoids remodel the DNA methylation patterns in breast cancer cells and inhibit oncogenic NOTCH signaling through epigenetic regulation of MAML2 transcriptional activity

DNA hypomethylation was previously implicated in cancer progression and metastasis. The purpose of this study was to examine whether stilbenoids, resveratrol and pterostilbene thought to exert anticancer effects, target genes with oncogenic function for de novo methylation and silencing, leading to...

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Veröffentlicht in:	Carcinogenesis (New York) 2016-07, Vol.37 (7), p.656-668
Hauptverfasser:	Lubecka, Katarzyna, Kurzava, Lucinda, Flower, Kirsty, Buvala, Hannah, Zhang, Hao, Teegarden, Dorothy, Camarillo, Ignacio, Suderman, Matthew, Kuang, Shihuan, Andrisani, Ourania, Flanagan, James M, Stefanska, Barbara
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - pathology Cell Line, Tumor Chromatin - drug effects CpG Islands - genetics DNA (Cytosine-5-)-Methyltransferases - biosynthesis DNA (Cytosine-5-)-Methyltransferases - genetics DNA Methylation - drug effects DNA Methyltransferase 3B DNA-Binding Proteins - genetics Female Gene Expression Regulation, Neoplastic - drug effects Genome, Human Humans Nuclear Proteins - genetics Organic Cation Transporter 1 - biosynthesis Organic Cation Transporter 1 - genetics Original Manuscript Promoter Regions, Genetic Receptors, Notch - genetics Resveratrol Signal Transduction - drug effects Stilbenes - administration & dosage Trans-Activators Transcription Factors - genetics Transcriptional Activation - genetics
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