GSK-3 directly regulates phospho-4EBP1 in renal cell carcinoma cell-line: an intrinsic subcellular mechanism for resistance to mTORC1 inhibition

The phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin 1 (mTORC1) signaling pathway is aberrantly activated in renal cell carcinoma (RCC). We previously demonstrated glycogen synthase kinase-3β (GSK-3β) positively regulated RCC proliferation. The aim of this study was to evaluate the...

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Veröffentlicht in:	BMC cancer 2016-07, Vol.16 (1), p.393-393, Article 393
Hauptverfasser:	Ito, Hiromi, Ichiyanagi, Osamu, Naito, Sei, Bilim, Vladimir N, Tomita, Yoshihiko, Kato, Tomoyuki, Nagaoka, Akira, Tsuchiya, Norihiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Apoptosis Cancer cells Carcinoma, Renal cell Carcinoma, Renal Cell - genetics Carcinoma, Renal Cell - metabolism Cell growth Cell Line, Tumor Cell lines Cell Proliferation - drug effects Cell Survival Chromones - pharmacology Cyclin-dependent kinases Drug Resistance, Neoplasm Gene Expression Regulation, Neoplastic - drug effects Glycogen Synthase Kinase 3 beta - genetics Glycogen Synthase Kinase 3 beta - metabolism Health aspects Humans Kidney cancer Kidney Neoplasms - genetics Kidney Neoplasms - metabolism Kinases Mechanistic Target of Rapamycin Complex 1 Metabolism Metastasis Morpholines - pharmacology Multiprotein Complexes - antagonists & inhibitors Mutation Phosphoproteins - genetics Phosphoproteins - metabolism Phosphorylation Phosphotransferases Physiological aspects Protein synthesis Proteins Rapamycin Ribosomal Protein S6 - genetics Ribosomal Protein S6 - metabolism Ribosomal Protein S6 Kinases - genetics Ribosomal Protein S6 Kinases - metabolism Signal transduction Signal Transduction - drug effects Sirolimus - pharmacology TOR Serine-Threonine Kinases - antagonists & inhibitors
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