Inverse Correlation between IL-10 and HIF-1α in Macrophages Infected with Histoplasma capsulatum

Hypoxia-inducible factor (HIF)-1α is a transcription factor that regulates metabolic and immune response genes in the setting of low oxygen tension and inflammation. We investigated the function of HIF-1α in the host response to Histoplasma capsulatum because granulomas induced by this pathogenic fu...

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Veröffentlicht in:	The Journal of immunology (1950) 2016-07, Vol.197 (2), p.565-579
Hauptverfasser:	Fecher, Roger A, Horwath, Michael C, Friedrich, Dirk, Rupp, Jan, Deepe, Jr, George S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western CREB-Binding Protein - immunology Disease Models, Animal Flow Cytometry Histoplasma - immunology Histoplasma capsulatum Histoplasmosis - immunology Hypoxia-Inducible Factor 1, alpha Subunit - immunology Interleukin-10 - immunology Macrophages - immunology Male Mice Mice, Inbred C57BL Mice, Knockout Microscopy, Confocal Real-Time Polymerase Chain Reaction
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