Keratin 8 knockdown leads to loss of the chloride transporter DRA in the colon

Keratins (K) are intermediate filament proteins important in protection from stress. The roles of keratins in the intestine are not clear, but K8 knockout (K8(-/-)) mice develop a Th2-type colonic inflammation, epithelial hyperproliferation, and mild diarrhea caused by a keratin level-dependent decr...

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Veröffentlicht in:	American journal of physiology: Gastrointestinal and liver physiology 2016-06, Vol.310 (11), p.G1147-G1154
Hauptverfasser:	Asghar, M Nadeem, Priyamvada, Shubha, Nyström, Joel H, Anbazhagan, Arivarasu Natarajan, Dudeja, Pradeep K, Toivola, Diana M
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Transport Systems - genetics Amino Acid Transport Systems - metabolism Animals Antiporters - genetics Antiporters - metabolism Caco-2 Cells Colon - metabolism Cystic Fibrosis Transmembrane Conductance Regulator - genetics Cystic Fibrosis Transmembrane Conductance Regulator - metabolism Epithelial Biology and Secretion Humans Keratin-8 - genetics Keratin-8 - metabolism Mice RNA, Messenger - genetics RNA, Messenger - metabolism Sodium-Hydrogen Exchanger 3 Sodium-Hydrogen Exchangers - genetics Sodium-Hydrogen Exchangers - metabolism Symporters - genetics Symporters - metabolism
Online-Zugang:	Volltext
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