Epithelial-mesenchymal transition: An emerging target in tissue fibrosis
Epithelial-mesenchymal transition (EMT) is involved in a variety of tissue fibroses. Fibroblasts/myofibroblasts derived from epithelial cells contribute to the excessive accumulation of fibrous connective tissue in damaged tissue, which can lead to permanent scarring or organ malfunction. Therefore,...
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| Veröffentlicht in: | Experimental Biology and Medicine 2016-01, Vol.241 (1), p.1-13 |
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| container_title | Experimental Biology and Medicine |
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| creator | Li, Meirong Luan, Fuxin Zhao, Yali Hao, Haojie Zhou, Yong Han, Weidong Fu, Xiaobing |
| description | Epithelial-mesenchymal transition (EMT) is involved in a variety of tissue fibroses. Fibroblasts/myofibroblasts derived from epithelial cells contribute to the excessive accumulation of fibrous connective tissue in damaged tissue, which can lead to permanent scarring or organ malfunction. Therefore, EMT-related fibrosis cannot be neglected. This review highlights the findings that demonstrate the EMT to be a direct contributor to the fibroblast/myofibroblast population in the development of tissue fibrosis and helps to elucidate EMT-related anti-fibrotic strategies, which may enable the development of therapeutic interventions to suppress EMT and potentially reverse organ fibrosis. |
| doi_str_mv | 10.1177/1535370215597194 |
| format | Article |
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Fibroblasts/myofibroblasts derived from epithelial cells contribute to the excessive accumulation of fibrous connective tissue in damaged tissue, which can lead to permanent scarring or organ malfunction. Therefore, EMT-related fibrosis cannot be neglected. This review highlights the findings that demonstrate the EMT to be a direct contributor to the fibroblast/myofibroblast population in the development of tissue fibrosis and helps to elucidate EMT-related anti-fibrotic strategies, which may enable the development of therapeutic interventions to suppress EMT and potentially reverse organ fibrosis.</description><identifier>ISSN: 1535-3702</identifier><identifier>EISSN: 1535-3699</identifier><identifier>DOI: 10.1177/1535370215597194</identifier><identifier>PMID: 26361988</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Epithelial-Mesenchymal Transition ; Fibrosis - pathology ; Fibrosis - therapy ; Humans ; Minireview</subject><ispartof>Experimental Biology and Medicine, 2016-01, Vol.241 (1), p.1-13</ispartof><rights>2016 by the Society for Experimental Biology and Medicine</rights><rights>2016 by the Society for Experimental Biology and Medicine.</rights><rights>2016 by the Society for Experimental Biology and Medicine 2016 The Society for Experimental Biology and Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c500t-9dc60849ba3e1b67858a3888f7d0353e9b543bbf9ea242f4bc976686e0b194623</citedby><cites>FETCH-LOGICAL-c500t-9dc60849ba3e1b67858a3888f7d0353e9b543bbf9ea242f4bc976686e0b194623</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935434/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935434/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,313,314,723,776,780,788,881,21798,27899,27901,27902,43597,43598,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26361988$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Meirong</creatorcontrib><creatorcontrib>Luan, Fuxin</creatorcontrib><creatorcontrib>Zhao, Yali</creatorcontrib><creatorcontrib>Hao, Haojie</creatorcontrib><creatorcontrib>Zhou, Yong</creatorcontrib><creatorcontrib>Han, Weidong</creatorcontrib><creatorcontrib>Fu, Xiaobing</creatorcontrib><title>Epithelial-mesenchymal transition: An emerging target in tissue fibrosis</title><title>Experimental Biology and Medicine</title><addtitle>Exp Biol Med (Maywood)</addtitle><description>Epithelial-mesenchymal transition (EMT) is involved in a variety of tissue fibroses. Fibroblasts/myofibroblasts derived from epithelial cells contribute to the excessive accumulation of fibrous connective tissue in damaged tissue, which can lead to permanent scarring or organ malfunction. Therefore, EMT-related fibrosis cannot be neglected. This review highlights the findings that demonstrate the EMT to be a direct contributor to the fibroblast/myofibroblast population in the development of tissue fibrosis and helps to elucidate EMT-related anti-fibrotic strategies, which may enable the development of therapeutic interventions to suppress EMT and potentially reverse organ fibrosis.</description><subject>Epithelial-Mesenchymal Transition</subject><subject>Fibrosis - pathology</subject><subject>Fibrosis - therapy</subject><subject>Humans</subject><subject>Minireview</subject><issn>1535-3702</issn><issn>1535-3699</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1PwzAMhiME4mNw54R65FJImjYfHJCmaTCkSVzgHCWd22Vq05G0SPv3ZNqGAImTI_v1E782QtcE3xHC-T0paEE5zkhRSE5kfoTOt6mUMimPD-9YP0MXIawwJgXP2Ck6yxhlRApxjmbTte2X0FjdpC0EcOVy0-om6b12wfa2cw_J2CXQgq-tq5Ne-xr6xLqktyEMkFTW-C7YcIlOKt0EuNrHEXp_mr5NZun89fllMp6nZYFxn8pFybDIpdEUiGFcFEJTIUTFFzh6AWmKnBpTSdBZnlW5KSVnTDDAJvpjGR2hxx13PZgWFiW4OGqj1t622m9Up636XXF2qeruU-WSRnQeAbd7gO8-Bgi9am0ooWm0g24IinBGco4ll1GKd9IyWgwequ9vCFbbA6i_B4gtNz_H-244bDwK0p0g6BrUqhu8i-v6H_gFBoyOgA</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Li, Meirong</creator><creator>Luan, Fuxin</creator><creator>Zhao, Yali</creator><creator>Hao, Haojie</creator><creator>Zhou, Yong</creator><creator>Han, Weidong</creator><creator>Fu, Xiaobing</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160101</creationdate><title>Epithelial-mesenchymal transition: An emerging target in tissue fibrosis</title><author>Li, Meirong ; Luan, Fuxin ; Zhao, Yali ; Hao, Haojie ; Zhou, Yong ; Han, Weidong ; Fu, Xiaobing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c500t-9dc60849ba3e1b67858a3888f7d0353e9b543bbf9ea242f4bc976686e0b194623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Epithelial-Mesenchymal Transition</topic><topic>Fibrosis - pathology</topic><topic>Fibrosis - therapy</topic><topic>Humans</topic><topic>Minireview</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Meirong</creatorcontrib><creatorcontrib>Luan, Fuxin</creatorcontrib><creatorcontrib>Zhao, Yali</creatorcontrib><creatorcontrib>Hao, Haojie</creatorcontrib><creatorcontrib>Zhou, Yong</creatorcontrib><creatorcontrib>Han, Weidong</creatorcontrib><creatorcontrib>Fu, Xiaobing</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Experimental Biology and Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Meirong</au><au>Luan, Fuxin</au><au>Zhao, Yali</au><au>Hao, Haojie</au><au>Zhou, Yong</au><au>Han, Weidong</au><au>Fu, Xiaobing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epithelial-mesenchymal transition: An emerging target in tissue fibrosis</atitle><jtitle>Experimental Biology and Medicine</jtitle><addtitle>Exp Biol Med (Maywood)</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>241</volume><issue>1</issue><spage>1</spage><epage>13</epage><pages>1-13</pages><issn>1535-3702</issn><eissn>1535-3699</eissn><abstract>Epithelial-mesenchymal transition (EMT) is involved in a variety of tissue fibroses. Fibroblasts/myofibroblasts derived from epithelial cells contribute to the excessive accumulation of fibrous connective tissue in damaged tissue, which can lead to permanent scarring or organ malfunction. Therefore, EMT-related fibrosis cannot be neglected. This review highlights the findings that demonstrate the EMT to be a direct contributor to the fibroblast/myofibroblast population in the development of tissue fibrosis and helps to elucidate EMT-related anti-fibrotic strategies, which may enable the development of therapeutic interventions to suppress EMT and potentially reverse organ fibrosis.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>26361988</pmid><doi>10.1177/1535370215597194</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; SAGE Complete; PubMed Central |
| subjects | Epithelial-Mesenchymal Transition Fibrosis - pathology Fibrosis - therapy Humans Minireview |
| title | Epithelial-mesenchymal transition: An emerging target in tissue fibrosis |
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