Local coupling of TRPC6 to ANO1/TMEM16A channels in smooth muscle cells amplifies vasoconstriction in cerebral arteries

Anoctamin-1 [ANO1, also known as transmembrane protein 16A (TMEM16A)] is a Ca(2+)-activated Cl(-) channel expressed in arterial myocytes that regulates membrane potential and contractility. Signaling mechanisms that control ANO1 activity in arterial myocytes are poorly understood. In cerebral artery...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	American Journal of Physiology: Cell Physiology 2016-06, Vol.310 (11), p.C1001-C1009
Hauptverfasser:	Wang, Qian, Leo, M Dennis, Narayanan, Damodaran, Kuruvilla, Korah P, Jaggar, Jonathan H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anoctamin-1 Calcium Chelating Agents - pharmacology Calcium Signaling Call for Papers Cerebral Arteries - metabolism Chloride Channels - antagonists & inhibitors Chloride Channels - genetics Chloride Channels - metabolism Male Membrane Potentials Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - metabolism Rats, Sprague-Dawley RNA Interference Tissue Culture Techniques Transfection TRPC Cation Channels - agonists TRPC Cation Channels - metabolism Vasoconstriction - drug effects Vasoconstrictor Agents - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!