Pregnancy Outcomes in the Tofacitinib Safety Databases for Rheumatoid Arthritis and Psoriasis

Introduction Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA), and is being investigated for the treatment of psoriasis. Both conditions can present in women of child-bearing potential, but pregnancy was an exclusion and discontinuation criterion in tofaci...

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Veröffentlicht in:	Drug safety 2016-08, Vol.39 (8), p.755-762
Hauptverfasser:	Clowse, Megan E. B., Feldman, Steven R., Isaacs, John D., Kimball, Alexandra B., Strand, Vibeke, Warren, Richard B., Xibillé, Daniel, Chen, Yan, Frazier, Donald, Geier, Jamie, Proulx, James, Marren, Amy
Format:	Artikel
Sprache:	eng
Schlagworte:	Abortion Adult Antirheumatic Agents - administration & dosage Antirheumatic Agents - adverse effects Arthritis, Rheumatoid - complications Arthritis, Rheumatoid - drug therapy Birth weight Databases, Factual Drug Safety and Pharmacovigilance Drug Therapy, Combination FDA approval Female Females Follow-Up Studies Funding Humans Infant, Newborn Medicine Medicine & Public Health Methotrexate - administration & dosage Original Original Research Article Patients Pharmaceutical industry Pharmacology/Toxicology Piperidines - administration & dosage Piperidines - adverse effects Pregnancy Pregnancy Outcome Protein Kinase Inhibitors - administration & dosage Protein Kinase Inhibitors - adverse effects Psoriasis Psoriasis - complications Psoriasis - drug therapy Pyrimidines - administration & dosage Pyrimidines - adverse effects Pyrroles - administration & dosage Pyrroles - adverse effects Randomized Controlled Trials as Topic Rheumatoid arthritis Studies Young Adult
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