Engineering Highly Potent and Selective Microproteins against Nav1.7 Sodium Channel for Treatment of Pain

The prominent role of voltage-gated sodium channel 1.7 (Nav1.7) in nociception was revealed by remarkable human clinical and genetic evidence. Development of potent and subtype-selective inhibitors of this ion channel is crucial for obtaining therapeutically useful analgesic compounds. Microproteins...

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Veröffentlicht in:	The Journal of biological chemistry 2016-07, Vol.291 (27), p.13974-13986
Hauptverfasser:	Shcherbatko, Anatoly, Rossi, Andrea, Foletti, Davide, Zhu, Guoyun, Bogin, Oren, Galindo Casas, Meritxell, Rickert, Mathias, Hasa-Moreno, Adela, Bartsevich, Victor, Crameri, Andreas, Steiner, Alexander R., Henningsen, Robert, Gill, Avinash, Pons, Jaume, Shelton, David L., Rajpal, Arvind, Strop, Pavel
Format:	Artikel
Sprache:	eng
Schlagworte:	ceratotoxin directed evolution engineering HEK293 Cells Humans Nav1.7 NAV1.7 Voltage-Gated Sodium Channel - chemistry NAV1.7 Voltage-Gated Sodium Channel - drug effects Neurobiology pain Pain Management - methods Patch-Clamp Techniques Phylogeny Protein Engineering sodium channel Spider Venoms - chemistry structure-function toxin Voltage-Gated Sodium Channel Blockers - pharmacology
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