Ethanol-induced GABAA receptor alpha4 subunit plasticity involves phosphorylation and neuroactive steroids

GABAA receptors containing α4 subunits are widely implicated in acute ethanol sensitivity, and their spatial and temporal regulation prominently contributes to ethanol-induced neuroplasticity in hippocampus and cortex. However, it is unknown if α4-containing GABAA receptors in the thalamus, an area...

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Veröffentlicht in:	Molecular and cellular neuroscience 2016-04, Vol.72, p.1-8
Hauptverfasser:	Werner, David F., Porcu, Patrizia, Boyd, Kevin N., O'Buckley, Todd K., Carter, Jenna M., Kumar, Sandeep, Morrow, A. Leslie
Format:	Artikel
Sprache:	eng
Schlagworte:	Alpha4 subunit Animals Ethanol Ethanol - pharmacology Finasteride - pharmacology GABA receptors Male Neuroactive steroids Neurotransmitter Agents - metabolism Phosphorylation PKC Protein Kinase C - metabolism Protein Kinase C-delta - metabolism Protein Processing, Post-Translational Protein Subunits - metabolism Rats Rats, Sprague-Dawley Receptors, GABA-A - genetics Receptors, GABA-A - metabolism Thalamus Thalamus - drug effects Thalamus - metabolism
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