Characterization of Atomoxetine Biotransformation and Implications for Development of PBPK Models for Dose Individualization in Children

Atomoxetine (ATX) is a second-line nonstimulant medication used to control symptoms of attention deficit hyperactivity disorder (ADHD). Inconsistent therapeutic efficacy has been reported with ATX, which may be related to variable CYP2D6-mediated drug clearance. We characterized ATX metabolism in a...

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Veröffentlicht in:	Drug metabolism and disposition 2016-07, Vol.44 (7), p.1070-1079
Hauptverfasser:	Dinh, Jean C, Pearce, Robin E, Van Haandel, Leon, Gaedigk, Andrea, Leeder, J Steven
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Age Factors Atomoxetine Hydrochloride - administration & dosage Atomoxetine Hydrochloride - pharmacokinetics Attention Deficit Disorder with Hyperactivity - diagnosis Attention Deficit Disorder with Hyperactivity - drug therapy Attention Deficit Disorder with Hyperactivity - psychology Biotransformation Central Nervous System Stimulants - administration & dosage Central Nervous System Stimulants - pharmacokinetics Child Cytochrome P-450 Enzyme System - genetics Cytochrome P-450 Enzyme System - metabolism Drug Dosage Calculations Genotype Humans Hydroxylation Infant Isoenzymes Methylation Microsomes, Liver - metabolism Middle Aged Models, Biological Phenols - pharmacokinetics Phenotype Propylamines - pharmacokinetics Special Section on Pediatric Drug Disposition and Pharmacokinetics Substrate Specificity Young Adult
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