SIRT2-Mediated Deacetylation and Tetramerization of Pyruvate Kinase Directs Glycolysis and Tumor Growth

Sirtuins participate in sensing nutrient availability and directing metabolic activity to match energy needs with energy production and consumption. However, the pivotal targets for sirtuins in cancer are mainly unknown. In this study, we identify the M2 isoform of pyruvate kinase (PKM2) as a critic...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2016-07, Vol.76 (13), p.3802-3812
Hauptverfasser:	Park, Seong-Hoon, Ozden, Ozkan, Liu, Guoxiang, Song, Ha Yong, Zhu, Yueming, Yan, Yufan, Zou, Xianghui, Kang, Hong-Jun, Jiang, Haiyan, Principe, Daniel R, Cha, Yong-Il, Roh, Meejeon, Vassilopoulos, Athanassios, Gius, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Animals Blotting, Western Breast Neoplasms - metabolism Breast Neoplasms - pathology Carrier Proteins - chemistry Carrier Proteins - metabolism Cell Proliferation Female Fluorescent Antibody Technique Glucose - metabolism Glycolysis Humans Immunoenzyme Techniques Membrane Proteins - chemistry Membrane Proteins - metabolism Mice Mice, Knockout Neoplasm Recurrence, Local - metabolism Neoplasm Recurrence, Local - pathology Neoplasm Staging Prognosis Sirtuin 2 - physiology Thyroid Hormone-Binding Proteins Thyroid Hormones - chemistry Thyroid Hormones - metabolism Tissue Array Analysis Tumor Cells, Cultured
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