Androgen Deprivation Followed by Acute Androgen Stimulation Selectively Sensitizes AR-Positive Prostate Cancer Cells to Ionizing Radiation

The current standard of care for patients with locally advanced prostate cancer is a combination of androgen deprivation and radiation therapy. Radiation is typically given with androgen suppression when testosterone levels are at their nadir. Recent reports have shown that androgen stimulation of a...

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Veröffentlicht in:	Clinical cancer research 2016-07, Vol.22 (13), p.3310-3319
Hauptverfasser:	Hedayati, Mohammad, Haffner, Michael C, Coulter, Jonathan B, Raval, Raju R, Zhang, Yonggang, Zhou, Haoming, Mian, Omar, Knight, Emma J, Razavi, Nina, Dalrymple, Susan, Isaacs, John T, Santos, Aileen, Hales, Russell, Nelson, William G, Yegnasubramanian, Srinivasan, DeWeese, Theodore L
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgen Antagonists - pharmacology Androgens - pharmacology Animals Apoptosis - drug effects Cell Line, Tumor Cell Proliferation - drug effects Cell Survival DNA Breaks, Double-Stranded - drug effects DNA Topoisomerases, Type II - genetics DNA Topoisomerases, Type II - metabolism Humans Male Mice Orchiectomy - methods Poly-ADP-Ribose Binding Proteins - genetics Poly-ADP-Ribose Binding Proteins - metabolism Prostatic Neoplasms - radiotherapy Radiation, Ionizing Receptors, Androgen - metabolism RNA Interference RNA, Small Interfering - genetics Xenograft Model Antitumor Assays
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