Dynamic Axonal Translation in Developing and Mature Visual Circuits

Local mRNA translation mediates the adaptive responses of axons to extrinsic signals, but direct evidence that it occurs in mammalian CNS axons in vivo is scant. We developed an axon-TRAP-RiboTag approach in mouse that allows deep-sequencing analysis of ribosome-bound mRNAs in the retinal ganglion c...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell 2016-06, Vol.166 (1), p.181-192
Hauptverfasser:	Shigeoka, Toshiaki, Jung, Hosung, Jung, Jane, Turner-Bridger, Benita, Ohk, Jiyeon, Lin, Julie Qiaojin, Amieux, Paul S., Holt, Christine E.
Format:	Artikel
Sprache:	eng
Schlagworte:	adults Alternative Splicing Animals axons Axons - metabolism ganglia Gene Expression Regulation, Developmental genes high-throughput nucleotide sequencing messenger RNA Mice neural networks neurodegenerative diseases Protein Biosynthesis Proteome - analysis Proteome - metabolism Retinal Ganglion Cells - metabolism Ribosomes - metabolism RNA, Messenger - analysis RNA, Messenger - metabolism Superior Colliculi - metabolism Synaptic Transmission synaptogenesis translation (genetics)
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!