Quantitative Susceptibility Mapping of Intracerebral Hemorrhages at Various Stages
Purpose To investigate the magnetic susceptibility of intracerebral hemorrhages (ICH) at various stages by applying quantitative susceptibility mapping (QSM). Materials and Methods Blood susceptibility was measured serially using QSM after venous blood withdrawal from healthy subjects. Forty‐two pat...
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| Veröffentlicht in: | Journal of magnetic resonance imaging 2016-08, Vol.44 (2), p.420-425 |
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| container_title | Journal of magnetic resonance imaging |
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| creator | Chang, Shixin Zhang, Jingwei Liu, Tian Tsiouris, Apostolos John Shou, Jian Nguyen, Thanh Leifer, Dana Wang, Yi Kovanlikaya, Ilhami |
| description | Purpose
To investigate the magnetic susceptibility of intracerebral hemorrhages (ICH) at various stages by applying quantitative susceptibility mapping (QSM).
Materials and Methods
Blood susceptibility was measured serially using QSM after venous blood withdrawal from healthy subjects. Forty‐two patients who provided written consent were recruited in this Institutional Review Board‐approved study. Gradient echo magnetic resonance imaging (MRI) data of the 42 patients (17 females; 64 ± 12 years) with ICH were processed with QSM. The susceptibilities of various blood products within hematomas were measured on QSM.
Results
Blood susceptibility continually increased and reached a plateau 96 hours after venous blood withdrawal. Hematomas at all stages were consistently hyperintense on QSM. Susceptibility was 0.57 ± 0.48, 1.30 ± 0.33, 1.14 ± 0.46, 0.40 ± 0.13, and 0.71 ± 0.31 ppm for hyperacute, acute, early subacute, late subacute, and chronic stages of hematomas, respectively. The susceptibility decrease from early subacute (1.14 ppm) to late subacute (0.4 ppm) was significant (P |
| doi_str_mv | 10.1002/jmri.25143 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4930428</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1804861506</sourcerecordid><originalsourceid>FETCH-LOGICAL-c6833-462a11096f39a61a029fb5545cd9b715292fcb5c89471682bdfc9b43e66cc8b73</originalsourceid><addsrcrecordid>eNqNkUlvFDEUhC0EIiFw4QeglrggpA7elwsSiiAzkAFlYblZbo974klv2O7A_HvcTDICDhEnW8_fK7mqAHiK4CGCEL9at8EfYoYouQf2EcO4xEzy-_kOGSmRhGIPPIpxDSFUirKHYA9zkceI7oOz09F0ySeT_LUrzsdo3ZB85RufNsXCDIPvVkVfF_MuBWNdcFUwTTFzbR_CpVm5WJhUfDHB92MsztM0eQwe1KaJ7snNeQA-v3t7cTQrTz4dz4_enJSWS0JKyrFBCCpeE2U4MhCrumKMMrtUlcg2FK5txaxUVCAucbWsraoocZxbKytBDsDrre4wVq1bWjd9sdFD8K0JG90br_9-6fylXvXXmioCKZZZ4MWNQOi_jy4m3frsv2lM57IdnSOSAiJF0P-gVHLEIM_o83_QdT-GLieRKcWgEDzXcicFiVKQkEnr5ZayoY8xuHrnDkE9da-n7vXv7jP87M88duht2RlAW-CHb9zmDin9fnE2vxUttzs-Jvdzt2PCleaCCKa_fjzWM3Q6W3ygF_ob-QVPdsgb</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1803990336</pqid></control><display><type>article</type><title>Quantitative Susceptibility Mapping of Intracerebral Hemorrhages at Various Stages</title><source>MEDLINE</source><source>Wiley Journals</source><source>Wiley Online Library Free Content</source><creator>Chang, Shixin ; Zhang, Jingwei ; Liu, Tian ; Tsiouris, Apostolos John ; Shou, Jian ; Nguyen, Thanh ; Leifer, Dana ; Wang, Yi ; Kovanlikaya, Ilhami</creator><creatorcontrib>Chang, Shixin ; Zhang, Jingwei ; Liu, Tian ; Tsiouris, Apostolos John ; Shou, Jian ; Nguyen, Thanh ; Leifer, Dana ; Wang, Yi ; Kovanlikaya, Ilhami</creatorcontrib><description>Purpose
To investigate the magnetic susceptibility of intracerebral hemorrhages (ICH) at various stages by applying quantitative susceptibility mapping (QSM).
Materials and Methods
Blood susceptibility was measured serially using QSM after venous blood withdrawal from healthy subjects. Forty‐two patients who provided written consent were recruited in this Institutional Review Board‐approved study. Gradient echo magnetic resonance imaging (MRI) data of the 42 patients (17 females; 64 ± 12 years) with ICH were processed with QSM. The susceptibilities of various blood products within hematomas were measured on QSM.
Results
Blood susceptibility continually increased and reached a plateau 96 hours after venous blood withdrawal. Hematomas at all stages were consistently hyperintense on QSM. Susceptibility was 0.57 ± 0.48, 1.30 ± 0.33, 1.14 ± 0.46, 0.40 ± 0.13, and 0.71 ± 0.31 ppm for hyperacute, acute, early subacute, late subacute, and chronic stages of hematomas, respectively. The susceptibility decrease from early subacute (1.14 ppm) to late subacute (0.4 ppm) was significant (P < 0.01).
Conclusion
QSM reveals positive susceptibility in hyperacute hematomas, indicating that even at their hyperacute stage, deoxyhemoglobin may exist throughout the hematoma volume, not just at its rim, as seen on conventional
T2* imaging. QSM also reveals a reduction of susceptibility from early subacute to late subacute ICH, suggesting that methemoglobin concentration decreases at the late subacute stage. J. Magn. Reson. Imaging 2016;44:420–425.</description><identifier>ISSN: 1053-1807</identifier><identifier>EISSN: 1522-2586</identifier><identifier>DOI: 10.1002/jmri.25143</identifier><identifier>PMID: 26718014</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Blood ; Cerebral Hemorrhage - diagnostic imaging ; Cerebral Hemorrhage - pathology ; Disease Progression ; Female ; Females ; Hematoma ; Hemorrhage ; Humans ; Image Interpretation, Computer-Assisted - methods ; Imaging, Three-Dimensional - methods ; intracerebral hemorrhage ; Magnetic Fields ; Magnetic Resonance Angiography - methods ; Magnetic resonance imaging ; Magnetic susceptibility ; Male ; Mapping ; Measurement methods ; Methemoglobin ; Middle Aged ; NMR ; Nuclear magnetic resonance ; Patients ; QSM ; Reproducibility of Results ; Sensitivity and Specificity ; Severity of Illness Index</subject><ispartof>Journal of magnetic resonance imaging, 2016-08, Vol.44 (2), p.420-425</ispartof><rights>2015 Wiley Periodicals, Inc.</rights><rights>2016 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6833-462a11096f39a61a029fb5545cd9b715292fcb5c89471682bdfc9b43e66cc8b73</citedby><cites>FETCH-LOGICAL-c6833-462a11096f39a61a029fb5545cd9b715292fcb5c89471682bdfc9b43e66cc8b73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmri.25143$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmri.25143$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26718014$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chang, Shixin</creatorcontrib><creatorcontrib>Zhang, Jingwei</creatorcontrib><creatorcontrib>Liu, Tian</creatorcontrib><creatorcontrib>Tsiouris, Apostolos John</creatorcontrib><creatorcontrib>Shou, Jian</creatorcontrib><creatorcontrib>Nguyen, Thanh</creatorcontrib><creatorcontrib>Leifer, Dana</creatorcontrib><creatorcontrib>Wang, Yi</creatorcontrib><creatorcontrib>Kovanlikaya, Ilhami</creatorcontrib><title>Quantitative Susceptibility Mapping of Intracerebral Hemorrhages at Various Stages</title><title>Journal of magnetic resonance imaging</title><addtitle>J. Magn. Reson. Imaging</addtitle><description>Purpose
To investigate the magnetic susceptibility of intracerebral hemorrhages (ICH) at various stages by applying quantitative susceptibility mapping (QSM).
Materials and Methods
Blood susceptibility was measured serially using QSM after venous blood withdrawal from healthy subjects. Forty‐two patients who provided written consent were recruited in this Institutional Review Board‐approved study. Gradient echo magnetic resonance imaging (MRI) data of the 42 patients (17 females; 64 ± 12 years) with ICH were processed with QSM. The susceptibilities of various blood products within hematomas were measured on QSM.
Results
Blood susceptibility continually increased and reached a plateau 96 hours after venous blood withdrawal. Hematomas at all stages were consistently hyperintense on QSM. Susceptibility was 0.57 ± 0.48, 1.30 ± 0.33, 1.14 ± 0.46, 0.40 ± 0.13, and 0.71 ± 0.31 ppm for hyperacute, acute, early subacute, late subacute, and chronic stages of hematomas, respectively. The susceptibility decrease from early subacute (1.14 ppm) to late subacute (0.4 ppm) was significant (P < 0.01).
Conclusion
QSM reveals positive susceptibility in hyperacute hematomas, indicating that even at their hyperacute stage, deoxyhemoglobin may exist throughout the hematoma volume, not just at its rim, as seen on conventional
T2* imaging. QSM also reveals a reduction of susceptibility from early subacute to late subacute ICH, suggesting that methemoglobin concentration decreases at the late subacute stage. J. Magn. Reson. Imaging 2016;44:420–425.</description><subject>Blood</subject><subject>Cerebral Hemorrhage - diagnostic imaging</subject><subject>Cerebral Hemorrhage - pathology</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Females</subject><subject>Hematoma</subject><subject>Hemorrhage</subject><subject>Humans</subject><subject>Image Interpretation, Computer-Assisted - methods</subject><subject>Imaging, Three-Dimensional - methods</subject><subject>intracerebral hemorrhage</subject><subject>Magnetic Fields</subject><subject>Magnetic Resonance Angiography - methods</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic susceptibility</subject><subject>Male</subject><subject>Mapping</subject><subject>Measurement methods</subject><subject>Methemoglobin</subject><subject>Middle Aged</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Patients</subject><subject>QSM</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>Severity of Illness Index</subject><issn>1053-1807</issn><issn>1522-2586</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUlvFDEUhC0EIiFw4QeglrggpA7elwsSiiAzkAFlYblZbo974klv2O7A_HvcTDICDhEnW8_fK7mqAHiK4CGCEL9at8EfYoYouQf2EcO4xEzy-_kOGSmRhGIPPIpxDSFUirKHYA9zkceI7oOz09F0ySeT_LUrzsdo3ZB85RufNsXCDIPvVkVfF_MuBWNdcFUwTTFzbR_CpVm5WJhUfDHB92MsztM0eQwe1KaJ7snNeQA-v3t7cTQrTz4dz4_enJSWS0JKyrFBCCpeE2U4MhCrumKMMrtUlcg2FK5txaxUVCAucbWsraoocZxbKytBDsDrre4wVq1bWjd9sdFD8K0JG90br_9-6fylXvXXmioCKZZZ4MWNQOi_jy4m3frsv2lM57IdnSOSAiJF0P-gVHLEIM_o83_QdT-GLieRKcWgEDzXcicFiVKQkEnr5ZayoY8xuHrnDkE9da-n7vXv7jP87M88duht2RlAW-CHb9zmDin9fnE2vxUttzs-Jvdzt2PCleaCCKa_fjzWM3Q6W3ygF_ob-QVPdsgb</recordid><startdate>201608</startdate><enddate>201608</enddate><creator>Chang, Shixin</creator><creator>Zhang, Jingwei</creator><creator>Liu, Tian</creator><creator>Tsiouris, Apostolos John</creator><creator>Shou, Jian</creator><creator>Nguyen, Thanh</creator><creator>Leifer, Dana</creator><creator>Wang, Yi</creator><creator>Kovanlikaya, Ilhami</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201608</creationdate><title>Quantitative Susceptibility Mapping of Intracerebral Hemorrhages at Various Stages</title><author>Chang, Shixin ; Zhang, Jingwei ; Liu, Tian ; Tsiouris, Apostolos John ; Shou, Jian ; Nguyen, Thanh ; Leifer, Dana ; Wang, Yi ; Kovanlikaya, Ilhami</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6833-462a11096f39a61a029fb5545cd9b715292fcb5c89471682bdfc9b43e66cc8b73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Blood</topic><topic>Cerebral Hemorrhage - diagnostic imaging</topic><topic>Cerebral Hemorrhage - pathology</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Females</topic><topic>Hematoma</topic><topic>Hemorrhage</topic><topic>Humans</topic><topic>Image Interpretation, Computer-Assisted - methods</topic><topic>Imaging, Three-Dimensional - methods</topic><topic>intracerebral hemorrhage</topic><topic>Magnetic Fields</topic><topic>Magnetic Resonance Angiography - methods</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic susceptibility</topic><topic>Male</topic><topic>Mapping</topic><topic>Measurement methods</topic><topic>Methemoglobin</topic><topic>Middle Aged</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Patients</topic><topic>QSM</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>Severity of Illness Index</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chang, Shixin</creatorcontrib><creatorcontrib>Zhang, Jingwei</creatorcontrib><creatorcontrib>Liu, Tian</creatorcontrib><creatorcontrib>Tsiouris, Apostolos John</creatorcontrib><creatorcontrib>Shou, Jian</creatorcontrib><creatorcontrib>Nguyen, Thanh</creatorcontrib><creatorcontrib>Leifer, Dana</creatorcontrib><creatorcontrib>Wang, Yi</creatorcontrib><creatorcontrib>Kovanlikaya, Ilhami</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chang, Shixin</au><au>Zhang, Jingwei</au><au>Liu, Tian</au><au>Tsiouris, Apostolos John</au><au>Shou, Jian</au><au>Nguyen, Thanh</au><au>Leifer, Dana</au><au>Wang, Yi</au><au>Kovanlikaya, Ilhami</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quantitative Susceptibility Mapping of Intracerebral Hemorrhages at Various Stages</atitle><jtitle>Journal of magnetic resonance imaging</jtitle><addtitle>J. Magn. Reson. Imaging</addtitle><date>2016-08</date><risdate>2016</risdate><volume>44</volume><issue>2</issue><spage>420</spage><epage>425</epage><pages>420-425</pages><issn>1053-1807</issn><eissn>1522-2586</eissn><abstract>Purpose
To investigate the magnetic susceptibility of intracerebral hemorrhages (ICH) at various stages by applying quantitative susceptibility mapping (QSM).
Materials and Methods
Blood susceptibility was measured serially using QSM after venous blood withdrawal from healthy subjects. Forty‐two patients who provided written consent were recruited in this Institutional Review Board‐approved study. Gradient echo magnetic resonance imaging (MRI) data of the 42 patients (17 females; 64 ± 12 years) with ICH were processed with QSM. The susceptibilities of various blood products within hematomas were measured on QSM.
Results
Blood susceptibility continually increased and reached a plateau 96 hours after venous blood withdrawal. Hematomas at all stages were consistently hyperintense on QSM. Susceptibility was 0.57 ± 0.48, 1.30 ± 0.33, 1.14 ± 0.46, 0.40 ± 0.13, and 0.71 ± 0.31 ppm for hyperacute, acute, early subacute, late subacute, and chronic stages of hematomas, respectively. The susceptibility decrease from early subacute (1.14 ppm) to late subacute (0.4 ppm) was significant (P < 0.01).
Conclusion
QSM reveals positive susceptibility in hyperacute hematomas, indicating that even at their hyperacute stage, deoxyhemoglobin may exist throughout the hematoma volume, not just at its rim, as seen on conventional
T2* imaging. QSM also reveals a reduction of susceptibility from early subacute to late subacute ICH, suggesting that methemoglobin concentration decreases at the late subacute stage. J. Magn. Reson. Imaging 2016;44:420–425.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>26718014</pmid><doi>10.1002/jmri.25143</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of magnetic resonance imaging, 2016-08, Vol.44 (2), p.420-425 |
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| source | MEDLINE; Wiley Journals; Wiley Online Library Free Content |
| subjects | Blood Cerebral Hemorrhage - diagnostic imaging Cerebral Hemorrhage - pathology Disease Progression Female Females Hematoma Hemorrhage Humans Image Interpretation, Computer-Assisted - methods Imaging, Three-Dimensional - methods intracerebral hemorrhage Magnetic Fields Magnetic Resonance Angiography - methods Magnetic resonance imaging Magnetic susceptibility Male Mapping Measurement methods Methemoglobin Middle Aged NMR Nuclear magnetic resonance Patients QSM Reproducibility of Results Sensitivity and Specificity Severity of Illness Index |
| title | Quantitative Susceptibility Mapping of Intracerebral Hemorrhages at Various Stages |
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