Dietary arginine silicate inositol complex increased bone healing: histologic and histomorphometric study
Arginine silicate inositol complex (ASI; arginine 49.5%, silicon 8.2%, and inositol 25%) is a novel material that is a bioavailable source of silicon and arginine. ASI offers potential benefits for vascular and bone health. The aim of this study was to evaluate the potential effects of ASI complex o...
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| Veröffentlicht in: | Drug design, development and therapy development and therapy, 2016-01, Vol.10, p.2081-2086 |
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| creator | Yaman, Ferhan Acikan, Izzet Dundar, Serkan Simsek, Sercan Gul, Mehmet Ozercan, Ibrahim Hanifi Komorowski, James Sahin, Kazim |
| description | Arginine silicate inositol complex (ASI; arginine 49.5%, silicon 8.2%, and inositol 25%) is a novel material that is a bioavailable source of silicon and arginine. ASI offers potential benefits for vascular and bone health.
The aim of this study was to evaluate the potential effects of ASI complex on bone healing of critical-sized defects in rats.
The rats were randomly assigned to two groups of 21 rats each. The control group was fed a standard diet for 12 weeks; after the first 8 weeks, a calvarial critical-sized defect was created, and the rats were sacrificed 7, 14, and 28 days later. The ASI group was fed a diet containing 1.81 g/kg of ASI for 12 weeks; after the first 8 weeks, a calvarial critical-sized defect was created, and the rats were sacrificed 7, 14, and 28 days later. The calvarial bones of all the rats were then harvested for evaluation.
Osteoblasts and osteoclasts were detected at higher levels in the ASI group compared with the control group at days 7, 14, and 28 of the calvarial defect (P |
| doi_str_mv | 10.2147/dddt.s109271 |
| format | Article |
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The aim of this study was to evaluate the potential effects of ASI complex on bone healing of critical-sized defects in rats.
The rats were randomly assigned to two groups of 21 rats each. The control group was fed a standard diet for 12 weeks; after the first 8 weeks, a calvarial critical-sized defect was created, and the rats were sacrificed 7, 14, and 28 days later. The ASI group was fed a diet containing 1.81 g/kg of ASI for 12 weeks; after the first 8 weeks, a calvarial critical-sized defect was created, and the rats were sacrificed 7, 14, and 28 days later. The calvarial bones of all the rats were then harvested for evaluation.
Osteoblasts and osteoclasts were detected at higher levels in the ASI group compared with the control group at days 7, 14, and 28 of the calvarial defect (P<0.05). New bone formation was detected at higher levels in the ASI group compared with the controls at day 28 (P<0.05). However, new bone formation was not detected at days 7 and 14 in both the groups (P>0.05).
ASI supplementation significantly improved bone tissue healing in rats with critical-sized defects. This study demonstrated that ASI can enhance bone repair and has potential as a therapeutic regimen in humans.</description><identifier>ISSN: 1177-8881</identifier><identifier>EISSN: 1177-8881</identifier><identifier>DOI: 10.2147/dddt.s109271</identifier><identifier>PMID: 27390517</identifier><language>eng</language><publisher>New Zealand: Dove Medical Press Limited</publisher><subject>Animal tissues ; Animals ; Arginine ; Arginine - administration & dosage ; Arginine - pharmacology ; Bioavailability ; Biocompatibility ; Biomedical materials ; Bone growth ; Bone healing ; Bone regeneration ; Bone Regeneration - drug effects ; Bones ; Collagen ; Defects ; Dentistry ; Diet ; Dietary Supplements ; Female ; Healing ; Health aspects ; Inositol ; Inositol - administration & dosage ; Inositol - pharmacology ; Laboratory animals ; Metabolism ; Microscopy ; Mineralization ; Original Research ; Osteoblasts ; Osteoblasts - drug effects ; Osteoblasts - pathology ; Osteoclasts ; Osteoclasts - drug effects ; Osteoclasts - pathology ; Osteogenesis ; Pharmacological research ; Rats ; Rats, Sprague-Dawley ; Silicates - administration & dosage ; Silicates - pharmacology ; Silicon ; Skin ; Statistical analysis ; Wound Healing - drug effects</subject><ispartof>Drug design, development and therapy, 2016-01, Vol.10, p.2081-2086</ispartof><rights>COPYRIGHT 2016 Dove Medical Press Limited</rights><rights>2016. This work is licensed under https://creativecommons.org/licenses/by-nc/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 Yaman et al. This work is published and licensed by Dove Medical Press Limited 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c609t-f0ca052c310d20d47dad75ef1f08359a058bf0cf1734efd74c4f0f35dc34d6de3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930222/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930222/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,3862,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27390517$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yaman, Ferhan</creatorcontrib><creatorcontrib>Acikan, Izzet</creatorcontrib><creatorcontrib>Dundar, Serkan</creatorcontrib><creatorcontrib>Simsek, Sercan</creatorcontrib><creatorcontrib>Gul, Mehmet</creatorcontrib><creatorcontrib>Ozercan, Ibrahim Hanifi</creatorcontrib><creatorcontrib>Komorowski, James</creatorcontrib><creatorcontrib>Sahin, Kazim</creatorcontrib><title>Dietary arginine silicate inositol complex increased bone healing: histologic and histomorphometric study</title><title>Drug design, development and therapy</title><addtitle>Drug Des Devel Ther</addtitle><description>Arginine silicate inositol complex (ASI; arginine 49.5%, silicon 8.2%, and inositol 25%) is a novel material that is a bioavailable source of silicon and arginine. ASI offers potential benefits for vascular and bone health.
The aim of this study was to evaluate the potential effects of ASI complex on bone healing of critical-sized defects in rats.
The rats were randomly assigned to two groups of 21 rats each. The control group was fed a standard diet for 12 weeks; after the first 8 weeks, a calvarial critical-sized defect was created, and the rats were sacrificed 7, 14, and 28 days later. The ASI group was fed a diet containing 1.81 g/kg of ASI for 12 weeks; after the first 8 weeks, a calvarial critical-sized defect was created, and the rats were sacrificed 7, 14, and 28 days later. The calvarial bones of all the rats were then harvested for evaluation.
Osteoblasts and osteoclasts were detected at higher levels in the ASI group compared with the control group at days 7, 14, and 28 of the calvarial defect (P<0.05). New bone formation was detected at higher levels in the ASI group compared with the controls at day 28 (P<0.05). However, new bone formation was not detected at days 7 and 14 in both the groups (P>0.05).
ASI supplementation significantly improved bone tissue healing in rats with critical-sized defects. This study demonstrated that ASI can enhance bone repair and has potential as a therapeutic regimen in humans.</description><subject>Animal tissues</subject><subject>Animals</subject><subject>Arginine</subject><subject>Arginine - administration & dosage</subject><subject>Arginine - pharmacology</subject><subject>Bioavailability</subject><subject>Biocompatibility</subject><subject>Biomedical materials</subject><subject>Bone growth</subject><subject>Bone healing</subject><subject>Bone regeneration</subject><subject>Bone Regeneration - drug effects</subject><subject>Bones</subject><subject>Collagen</subject><subject>Defects</subject><subject>Dentistry</subject><subject>Diet</subject><subject>Dietary Supplements</subject><subject>Female</subject><subject>Healing</subject><subject>Health aspects</subject><subject>Inositol</subject><subject>Inositol - administration & dosage</subject><subject>Inositol - pharmacology</subject><subject>Laboratory animals</subject><subject>Metabolism</subject><subject>Microscopy</subject><subject>Mineralization</subject><subject>Original Research</subject><subject>Osteoblasts</subject><subject>Osteoblasts - drug effects</subject><subject>Osteoblasts - pathology</subject><subject>Osteoclasts</subject><subject>Osteoclasts - drug effects</subject><subject>Osteoclasts - pathology</subject><subject>Osteogenesis</subject><subject>Pharmacological research</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Silicates - administration & dosage</subject><subject>Silicates - pharmacology</subject><subject>Silicon</subject><subject>Skin</subject><subject>Statistical analysis</subject><subject>Wound Healing - drug effects</subject><issn>1177-8881</issn><issn>1177-8881</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkt9rFDEQx4Motp6--SwLgvTBO_Njd7PbB6H0_AUFH6zPIZdMblOyyZlkxf73zbG13okPEsIkk898M5kMQi8JXlFS83da67xKBPeUk0folBDOl13XkccH6xP0LKUbjFvWUvwUnVDOetwQfors2kKW8baScWu99VAl66ySGSrrQ7I5uEqFcefgV3GoCDKBrjahgANIZ_32vBpsKljYWlVJr-ftGOJuCCPkWLwpT_r2OXpipEvw4t4u0PePH64vPy-vvn76cnlxtVQt7vPSYCVxQxUjWFOsa66l5g0YYnDHmr6cdZvCGMJZDUbzWtUGG9ZoxWrdamAL9H7W3U2bEbQCn6N0YhftWN4pgrTi-MTbQWzDT1H3DFNKi8DZvUAMPyZIWYw2KXBOeghTEqTDHWe8mP9BGe9pU1JfoNd_oTdhir5UQpRL26ZMjv9QW-lAWG9CSVHtRcVFg9uWsllr9Q-qDA2jVeVvjC3-o4A3BwH7j8tDCm7KNvh0DL6dQRVDShHMQ90IFvt2E-v1-lp8m9ut4K8Oa_0A_-4vdgfOO9Dz</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Yaman, Ferhan</creator><creator>Acikan, Izzet</creator><creator>Dundar, Serkan</creator><creator>Simsek, Sercan</creator><creator>Gul, Mehmet</creator><creator>Ozercan, Ibrahim Hanifi</creator><creator>Komorowski, James</creator><creator>Sahin, Kazim</creator><general>Dove Medical Press Limited</general><general>Taylor & Francis Ltd</general><general>Dove Medical Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7XB</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>KB0</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160101</creationdate><title>Dietary arginine silicate inositol complex increased bone healing: histologic and histomorphometric study</title><author>Yaman, Ferhan ; Acikan, Izzet ; Dundar, Serkan ; Simsek, Sercan ; Gul, Mehmet ; Ozercan, Ibrahim Hanifi ; Komorowski, James ; Sahin, Kazim</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c609t-f0ca052c310d20d47dad75ef1f08359a058bf0cf1734efd74c4f0f35dc34d6de3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animal tissues</topic><topic>Animals</topic><topic>Arginine</topic><topic>Arginine - administration & dosage</topic><topic>Arginine - pharmacology</topic><topic>Bioavailability</topic><topic>Biocompatibility</topic><topic>Biomedical materials</topic><topic>Bone growth</topic><topic>Bone healing</topic><topic>Bone regeneration</topic><topic>Bone Regeneration - drug effects</topic><topic>Bones</topic><topic>Collagen</topic><topic>Defects</topic><topic>Dentistry</topic><topic>Diet</topic><topic>Dietary Supplements</topic><topic>Female</topic><topic>Healing</topic><topic>Health aspects</topic><topic>Inositol</topic><topic>Inositol - administration & dosage</topic><topic>Inositol - pharmacology</topic><topic>Laboratory animals</topic><topic>Metabolism</topic><topic>Microscopy</topic><topic>Mineralization</topic><topic>Original Research</topic><topic>Osteoblasts</topic><topic>Osteoblasts - drug effects</topic><topic>Osteoblasts - pathology</topic><topic>Osteoclasts</topic><topic>Osteoclasts - drug effects</topic><topic>Osteoclasts - pathology</topic><topic>Osteogenesis</topic><topic>Pharmacological research</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Silicates - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Drug design, development and therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yaman, Ferhan</au><au>Acikan, Izzet</au><au>Dundar, Serkan</au><au>Simsek, Sercan</au><au>Gul, Mehmet</au><au>Ozercan, Ibrahim Hanifi</au><au>Komorowski, James</au><au>Sahin, Kazim</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dietary arginine silicate inositol complex increased bone healing: histologic and histomorphometric study</atitle><jtitle>Drug design, development and therapy</jtitle><addtitle>Drug Des Devel Ther</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>10</volume><spage>2081</spage><epage>2086</epage><pages>2081-2086</pages><issn>1177-8881</issn><eissn>1177-8881</eissn><abstract>Arginine silicate inositol complex (ASI; arginine 49.5%, silicon 8.2%, and inositol 25%) is a novel material that is a bioavailable source of silicon and arginine. ASI offers potential benefits for vascular and bone health.
The aim of this study was to evaluate the potential effects of ASI complex on bone healing of critical-sized defects in rats.
The rats were randomly assigned to two groups of 21 rats each. The control group was fed a standard diet for 12 weeks; after the first 8 weeks, a calvarial critical-sized defect was created, and the rats were sacrificed 7, 14, and 28 days later. The ASI group was fed a diet containing 1.81 g/kg of ASI for 12 weeks; after the first 8 weeks, a calvarial critical-sized defect was created, and the rats were sacrificed 7, 14, and 28 days later. The calvarial bones of all the rats were then harvested for evaluation.
Osteoblasts and osteoclasts were detected at higher levels in the ASI group compared with the control group at days 7, 14, and 28 of the calvarial defect (P<0.05). New bone formation was detected at higher levels in the ASI group compared with the controls at day 28 (P<0.05). However, new bone formation was not detected at days 7 and 14 in both the groups (P>0.05).
ASI supplementation significantly improved bone tissue healing in rats with critical-sized defects. This study demonstrated that ASI can enhance bone repair and has potential as a therapeutic regimen in humans.</abstract><cop>New Zealand</cop><pub>Dove Medical Press Limited</pub><pmid>27390517</pmid><doi>10.2147/dddt.s109271</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | Taylor & Francis Open Access; MEDLINE; DOVE Medical Press Journals; DOAJ Directory of Open Access Journals; PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Animal tissues Animals Arginine Arginine - administration & dosage Arginine - pharmacology Bioavailability Biocompatibility Biomedical materials Bone growth Bone healing Bone regeneration Bone Regeneration - drug effects Bones Collagen Defects Dentistry Diet Dietary Supplements Female Healing Health aspects Inositol Inositol - administration & dosage Inositol - pharmacology Laboratory animals Metabolism Microscopy Mineralization Original Research Osteoblasts Osteoblasts - drug effects Osteoblasts - pathology Osteoclasts Osteoclasts - drug effects Osteoclasts - pathology Osteogenesis Pharmacological research Rats Rats, Sprague-Dawley Silicates - administration & dosage Silicates - pharmacology Silicon Skin Statistical analysis Wound Healing - drug effects |
| title | Dietary arginine silicate inositol complex increased bone healing: histologic and histomorphometric study |
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