Of rodents and humans: A comparative review of the neurobehavioral effects of early life SSRI exposure in preclinical and clinical research

•Children exposed to SSRI antidepressants in early life display changes in affective behavior, such as increased anxiety and depression-like behaviors and increased risk for autism. This review summarizes the known effects of early life SSRI exposure in humans and rodents and highlights molecular me...

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Veröffentlicht in:	International journal of developmental neuroscience 2016-06, Vol.51 (1), p.50-72
Hauptverfasser:	Glover, Matthew E., Clinton, Sarah M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anxiety Behavior Depression Drug Evaluation, Preclinical Epigenetics Female Hippocampus Hippocampus - drug effects Hippocampus - metabolism Humans Limbic System - drug effects Limbic System - growth & development Mood Disorders - etiology Neurogenesis Pregnancy Prenatal Exposure Delayed Effects - chemically induced Rodent models Serotonin Serotonin - metabolism Serotonin Uptake Inhibitors - pharmacology Signal Transduction - drug effects Signal Transduction - physiology SSRI
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