Loss of Ezh2 cooperates with Jak2V617F in the development of myelofibrosis in a mouse model of myeloproliferative neoplasm

An activating JAK2V617F mutation has been found in ∼50% patients with myelofibrosis (MF). Inactivating mutations in histone methyltransferase enhancer of zeste homolog 2 (EZH2) also have been observed in patients with MF. Interestingly, inactivating EZH2 mutations are often associated with JAK2V617F...

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Veröffentlicht in:	Blood 2016-06, Vol.127 (26), p.3410-3423
Hauptverfasser:	Yang, Yue, Akada, Hajime, Nath, Dipmoy, Hutchison, Robert E., Mohi, Golam
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Animals Enhancer of Zeste Homolog 2 Protein - deficiency Gene Deletion Gene Expression Regulation, Neoplastic Hematologic Neoplasms - genetics Hematologic Neoplasms - metabolism Janus Kinase 2 - genetics Janus Kinase 2 - metabolism Megakaryocyte Progenitor Cells - metabolism Megakaryocyte Progenitor Cells - pathology Mice Mice, Transgenic Mutation, Missense Myeloid Neoplasia Platelet Count Primary Myelofibrosis - genetics Primary Myelofibrosis - metabolism Primary Myelofibrosis - pathology
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