Cell-free expression of functional receptor tyrosine kinases

Receptor tyrosine kinases (RTKs) play critical roles in physiological and pathological processes and are important anticancer drug targets. In vitro mechanistic and drug discovery studies of full-length RTKs require protein that is both fully functional and free from contaminating proteins. Here we...

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Veröffentlicht in:	Scientific reports 2015-08, Vol.5 (1), p.12896-12896, Article 12896
Hauptverfasser:	He, Wei, Scharadin, Tiffany M., Saldana, Matthew, Gellner, Candice, Hoang-Phou, Steven, Takanishi, Christina, Hura, Gregory L., Tainer, John A, Carraway III, Kermit L., Henderson, Paul T., Coleman, Matthew A.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45/612/1237 692/699/67/1347 82 82/80 Apolipoprotein A Apolipoprotein A-I BASIC BIOLOGICAL SCIENCES Cell-Free System Cyclin-dependent kinases Drug discovery Epidermal growth factor receptors ErbB-2 protein Humanities and Social Sciences multidisciplinary Receptor Protein-Tyrosine Kinases - metabolism Science Tyrosine
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