Dopamine D1 signaling organizes network dynamics underlying working memory

Local prefrontal dopamine signaling supports working memory by tuning pyramidal neurons to task-relevant stimuli. Enabled by simultaneous positron emission tomography-magnetic resonance imaging (PET-MRI), we determined whether neuromodulatory effects of dopamine scale to the level of cortical networ...

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Veröffentlicht in:	Science advances 2016-06, Vol.2 (6), p.e1501672-e1501672
Hauptverfasser:	Roffman, Joshua L, Tanner, Alexandra S, Eryilmaz, Hamdi, Rodriguez-Thompson, Anais, Silverstein, Noah J, Ho, New Fei, Nitenson, Adam Z, Chonde, Daniel B, Greve, Douglas N, Abi-Dargham, Anissa, Buckner, Randy L, Manoach, Dara S, Rosen, Bruce R, Hooker, Jacob M, Catana, Ciprian
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Cerebral Cortex - physiology Corpus Striatum - physiology Dopamine - metabolism Female Humans Magnetic Resonance Imaging Male Memory, Short-Term Middle Aged Nerve Net Neurochemistry Positron-Emission Tomography Receptors, Dopamine D1 - metabolism SciAdv r-articles Signal Transduction Young Adult
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