Waiting Time from Diagnosis to Treatment has no Impact on Survival in Patients with Esophageal Cancer
Background Waiting time from diagnosis to treatment has emerged as an important quality indicator in cancer care. This study was designed to determine the impact of waiting time on long-term outcome of patients with esophageal cancer who are treated with neoadjuvant therapy followed by surgery or pr...
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| Veröffentlicht in: | Annals of surgical oncology 2016-08, Vol.23 (8), p.2679-2689 |
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| container_title | Annals of surgical oncology |
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| creator | Visser, E. Leeftink, A. G. van Rossum, P. S. N. Siesling, S. van Hillegersberg, R. Ruurda, J. P. |
| description | Background
Waiting time from diagnosis to treatment has emerged as an important quality indicator in cancer care. This study was designed to determine the impact of waiting time on long-term outcome of patients with esophageal cancer who are treated with neoadjuvant therapy followed by surgery or primary surgery.
Methods
Patients who underwent esophagectomy for esophageal cancer at the University Medical Center Utrecht between 2003 and 2014 were included. Patients treated with neoadjuvant therapy followed by surgery and treated with primary surgery were separately analyzed. The influence of waiting time on survival was analyzed using Cox proportional hazard analyses. Kaplan–Meier curves for short ( |
| doi_str_mv | 10.1245/s10434-016-5191-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4927609</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4103966641</sourcerecordid><originalsourceid>FETCH-LOGICAL-c470t-a3adf78f362347b856a9a0ab23cc606c60cf1e4d2eea25073f2aad21e80bf1e23</originalsourceid><addsrcrecordid>eNp1kV9rFDEUxYMotlY_gC8S8MWX0Zs_k5l5EWStWii04IqP4W42M5syk6xJZsVvb4atpS34EBJyfvfcezmEvGbwnnFZf0gMpJAVMFXVrGOVekJOWV1-pGrZ0_IG1VYdV_UJeZHSDQBrBNTPyQlvgPGubU-J_YkuOz_QtZss7WOY6GeHgw_JJZoDXUeLebI-0x0m6gO9mPZoMg2efp_jwR1wpM7Ta8yuQIn-dnlHz1PY73CwRVuhNza-JM96HJN9dXufkR9fzterb9Xl1deL1afLysgGcoUCt33T9kJxIZtNWyvsEHDDhTEKVDmmZ1ZuubXIa2hEzxG3nNkWNkXg4ox8PPru581kt6aMFHHU--gmjH90QKcfKt7t9BAOWna8UdAVg3e3BjH8mm3KenLJ2HFEb8OcNGuBScF4s_R6-wi9CXP0Zb2FAiFaDqpQ7EiZGFKKtr8bhoFeQtTHEHUJUS8h6qXmzf0t7ir-pVYAfgRSkfxg473W_3X9C_KWqJM</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1800338206</pqid></control><display><type>article</type><title>Waiting Time from Diagnosis to Treatment has no Impact on Survival in Patients with Esophageal Cancer</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Visser, E. ; Leeftink, A. G. ; van Rossum, P. S. N. ; Siesling, S. ; van Hillegersberg, R. ; Ruurda, J. P.</creator><creatorcontrib>Visser, E. ; Leeftink, A. G. ; van Rossum, P. S. N. ; Siesling, S. ; van Hillegersberg, R. ; Ruurda, J. P.</creatorcontrib><description>Background
Waiting time from diagnosis to treatment has emerged as an important quality indicator in cancer care. This study was designed to determine the impact of waiting time on long-term outcome of patients with esophageal cancer who are treated with neoadjuvant therapy followed by surgery or primary surgery.
Methods
Patients who underwent esophagectomy for esophageal cancer at the University Medical Center Utrecht between 2003 and 2014 were included. Patients treated with neoadjuvant therapy followed by surgery and treated with primary surgery were separately analyzed. The influence of waiting time on survival was analyzed using Cox proportional hazard analyses. Kaplan–Meier curves for short (<8 weeks) and long (≥8 weeks) waiting times were constructed.
Results
A total of 351 patients were included; 214 received neoadjuvant treatment, and 137 underwent primary surgery. In the neoadjuvant group, the waiting time had no impact on disease-free survival (DFS) [hazard ratio (HR) 0.96, 95 % confidence interval (CI) 0.88–1.04;
p
= 0.312] or overall survival (OS) (HR 0.96, 95 % CI 0.88–1.05;
p
= 0.372). Accordingly, no differences were found between neoadjuvantly treated patients with waiting times of <8 and ≥8 weeks in terms of DFS (
p
= 0.506) and OS (
p
= 0.693). In the primary surgery group, the waiting time had no impact on DFS (HR 1.03, 95 % CI 0.95–1.12; p = 0.443) or OS (HR 1.06, 95 % CI 0.99–1.13;
p
= 0.108). Waiting times of <8 weeks versus ≥8 weeks did not result in differences regarding DFS (
p
= 0.884) or OS (
p
= 0.374).
Conclusions
In esophageal cancer patients treated with curative intent by either neoadjuvant therapy followed by surgery or primary surgery, waiting time from diagnosis to treatment has no impact on long-term outcome.</description><identifier>ISSN: 1068-9265</identifier><identifier>EISSN: 1534-4681</identifier><identifier>DOI: 10.1245/s10434-016-5191-6</identifier><identifier>PMID: 27012988</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Adenocarcinoma - diagnosis ; Adenocarcinoma - mortality ; Adenocarcinoma - surgery ; Carcinoma, Squamous Cell - diagnosis ; Carcinoma, Squamous Cell - mortality ; Carcinoma, Squamous Cell - surgery ; Esophageal Neoplasms - diagnosis ; Esophageal Neoplasms - mortality ; Esophageal Neoplasms - surgery ; Esophagectomy - mortality ; Female ; Follow-Up Studies ; Humans ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Oncology ; Surgery ; Surgical Oncology ; Survival Rate ; Thoracic Oncology ; Time-to-Treatment ; Treatment Outcome</subject><ispartof>Annals of surgical oncology, 2016-08, Vol.23 (8), p.2679-2689</ispartof><rights>The Author(s) 2016</rights><rights>Society of Surgical Oncology 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-a3adf78f362347b856a9a0ab23cc606c60cf1e4d2eea25073f2aad21e80bf1e23</citedby><cites>FETCH-LOGICAL-c470t-a3adf78f362347b856a9a0ab23cc606c60cf1e4d2eea25073f2aad21e80bf1e23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1245/s10434-016-5191-6$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1245/s10434-016-5191-6$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27012988$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Visser, E.</creatorcontrib><creatorcontrib>Leeftink, A. G.</creatorcontrib><creatorcontrib>van Rossum, P. S. N.</creatorcontrib><creatorcontrib>Siesling, S.</creatorcontrib><creatorcontrib>van Hillegersberg, R.</creatorcontrib><creatorcontrib>Ruurda, J. P.</creatorcontrib><title>Waiting Time from Diagnosis to Treatment has no Impact on Survival in Patients with Esophageal Cancer</title><title>Annals of surgical oncology</title><addtitle>Ann Surg Oncol</addtitle><addtitle>Ann Surg Oncol</addtitle><description>Background
Waiting time from diagnosis to treatment has emerged as an important quality indicator in cancer care. This study was designed to determine the impact of waiting time on long-term outcome of patients with esophageal cancer who are treated with neoadjuvant therapy followed by surgery or primary surgery.
Methods
Patients who underwent esophagectomy for esophageal cancer at the University Medical Center Utrecht between 2003 and 2014 were included. Patients treated with neoadjuvant therapy followed by surgery and treated with primary surgery were separately analyzed. The influence of waiting time on survival was analyzed using Cox proportional hazard analyses. Kaplan–Meier curves for short (<8 weeks) and long (≥8 weeks) waiting times were constructed.
Results
A total of 351 patients were included; 214 received neoadjuvant treatment, and 137 underwent primary surgery. In the neoadjuvant group, the waiting time had no impact on disease-free survival (DFS) [hazard ratio (HR) 0.96, 95 % confidence interval (CI) 0.88–1.04;
p
= 0.312] or overall survival (OS) (HR 0.96, 95 % CI 0.88–1.05;
p
= 0.372). Accordingly, no differences were found between neoadjuvantly treated patients with waiting times of <8 and ≥8 weeks in terms of DFS (
p
= 0.506) and OS (
p
= 0.693). In the primary surgery group, the waiting time had no impact on DFS (HR 1.03, 95 % CI 0.95–1.12; p = 0.443) or OS (HR 1.06, 95 % CI 0.99–1.13;
p
= 0.108). Waiting times of <8 weeks versus ≥8 weeks did not result in differences regarding DFS (
p
= 0.884) or OS (
p
= 0.374).
Conclusions
In esophageal cancer patients treated with curative intent by either neoadjuvant therapy followed by surgery or primary surgery, waiting time from diagnosis to treatment has no impact on long-term outcome.</description><subject>Adenocarcinoma - diagnosis</subject><subject>Adenocarcinoma - mortality</subject><subject>Adenocarcinoma - surgery</subject><subject>Carcinoma, Squamous Cell - diagnosis</subject><subject>Carcinoma, Squamous Cell - mortality</subject><subject>Carcinoma, Squamous Cell - surgery</subject><subject>Esophageal Neoplasms - diagnosis</subject><subject>Esophageal Neoplasms - mortality</subject><subject>Esophageal Neoplasms - surgery</subject><subject>Esophagectomy - mortality</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Oncology</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Survival Rate</subject><subject>Thoracic Oncology</subject><subject>Time-to-Treatment</subject><subject>Treatment Outcome</subject><issn>1068-9265</issn><issn>1534-4681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kV9rFDEUxYMotlY_gC8S8MWX0Zs_k5l5EWStWii04IqP4W42M5syk6xJZsVvb4atpS34EBJyfvfcezmEvGbwnnFZf0gMpJAVMFXVrGOVekJOWV1-pGrZ0_IG1VYdV_UJeZHSDQBrBNTPyQlvgPGubU-J_YkuOz_QtZss7WOY6GeHgw_JJZoDXUeLebI-0x0m6gO9mPZoMg2efp_jwR1wpM7Ta8yuQIn-dnlHz1PY73CwRVuhNza-JM96HJN9dXufkR9fzterb9Xl1deL1afLysgGcoUCt33T9kJxIZtNWyvsEHDDhTEKVDmmZ1ZuubXIa2hEzxG3nNkWNkXg4ox8PPru581kt6aMFHHU--gmjH90QKcfKt7t9BAOWna8UdAVg3e3BjH8mm3KenLJ2HFEb8OcNGuBScF4s_R6-wi9CXP0Zb2FAiFaDqpQ7EiZGFKKtr8bhoFeQtTHEHUJUS8h6qXmzf0t7ir-pVYAfgRSkfxg473W_3X9C_KWqJM</recordid><startdate>20160801</startdate><enddate>20160801</enddate><creator>Visser, E.</creator><creator>Leeftink, A. G.</creator><creator>van Rossum, P. S. N.</creator><creator>Siesling, S.</creator><creator>van Hillegersberg, R.</creator><creator>Ruurda, J. P.</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160801</creationdate><title>Waiting Time from Diagnosis to Treatment has no Impact on Survival in Patients with Esophageal Cancer</title><author>Visser, E. ; Leeftink, A. G. ; van Rossum, P. S. N. ; Siesling, S. ; van Hillegersberg, R. ; Ruurda, J. P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-a3adf78f362347b856a9a0ab23cc606c60cf1e4d2eea25073f2aad21e80bf1e23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adenocarcinoma - diagnosis</topic><topic>Adenocarcinoma - mortality</topic><topic>Adenocarcinoma - surgery</topic><topic>Carcinoma, Squamous Cell - diagnosis</topic><topic>Carcinoma, Squamous Cell - mortality</topic><topic>Carcinoma, Squamous Cell - surgery</topic><topic>Esophageal Neoplasms - diagnosis</topic><topic>Esophageal Neoplasms - mortality</topic><topic>Esophageal Neoplasms - surgery</topic><topic>Esophagectomy - mortality</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Oncology</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Survival Rate</topic><topic>Thoracic Oncology</topic><topic>Time-to-Treatment</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Visser, E.</creatorcontrib><creatorcontrib>Leeftink, A. G.</creatorcontrib><creatorcontrib>van Rossum, P. S. N.</creatorcontrib><creatorcontrib>Siesling, S.</creatorcontrib><creatorcontrib>van Hillegersberg, R.</creatorcontrib><creatorcontrib>Ruurda, J. P.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Annals of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Visser, E.</au><au>Leeftink, A. G.</au><au>van Rossum, P. S. N.</au><au>Siesling, S.</au><au>van Hillegersberg, R.</au><au>Ruurda, J. P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Waiting Time from Diagnosis to Treatment has no Impact on Survival in Patients with Esophageal Cancer</atitle><jtitle>Annals of surgical oncology</jtitle><stitle>Ann Surg Oncol</stitle><addtitle>Ann Surg Oncol</addtitle><date>2016-08-01</date><risdate>2016</risdate><volume>23</volume><issue>8</issue><spage>2679</spage><epage>2689</epage><pages>2679-2689</pages><issn>1068-9265</issn><eissn>1534-4681</eissn><abstract>Background
Waiting time from diagnosis to treatment has emerged as an important quality indicator in cancer care. This study was designed to determine the impact of waiting time on long-term outcome of patients with esophageal cancer who are treated with neoadjuvant therapy followed by surgery or primary surgery.
Methods
Patients who underwent esophagectomy for esophageal cancer at the University Medical Center Utrecht between 2003 and 2014 were included. Patients treated with neoadjuvant therapy followed by surgery and treated with primary surgery were separately analyzed. The influence of waiting time on survival was analyzed using Cox proportional hazard analyses. Kaplan–Meier curves for short (<8 weeks) and long (≥8 weeks) waiting times were constructed.
Results
A total of 351 patients were included; 214 received neoadjuvant treatment, and 137 underwent primary surgery. In the neoadjuvant group, the waiting time had no impact on disease-free survival (DFS) [hazard ratio (HR) 0.96, 95 % confidence interval (CI) 0.88–1.04;
p
= 0.312] or overall survival (OS) (HR 0.96, 95 % CI 0.88–1.05;
p
= 0.372). Accordingly, no differences were found between neoadjuvantly treated patients with waiting times of <8 and ≥8 weeks in terms of DFS (
p
= 0.506) and OS (
p
= 0.693). In the primary surgery group, the waiting time had no impact on DFS (HR 1.03, 95 % CI 0.95–1.12; p = 0.443) or OS (HR 1.06, 95 % CI 0.99–1.13;
p
= 0.108). Waiting times of <8 weeks versus ≥8 weeks did not result in differences regarding DFS (
p
= 0.884) or OS (
p
= 0.374).
Conclusions
In esophageal cancer patients treated with curative intent by either neoadjuvant therapy followed by surgery or primary surgery, waiting time from diagnosis to treatment has no impact on long-term outcome.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>27012988</pmid><doi>10.1245/s10434-016-5191-6</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1068-9265 |
| ispartof | Annals of surgical oncology, 2016-08, Vol.23 (8), p.2679-2689 |
| issn | 1068-9265 1534-4681 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4927609 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adenocarcinoma - diagnosis Adenocarcinoma - mortality Adenocarcinoma - surgery Carcinoma, Squamous Cell - diagnosis Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - surgery Esophageal Neoplasms - diagnosis Esophageal Neoplasms - mortality Esophageal Neoplasms - surgery Esophagectomy - mortality Female Follow-Up Studies Humans Male Medicine Medicine & Public Health Middle Aged Oncology Surgery Surgical Oncology Survival Rate Thoracic Oncology Time-to-Treatment Treatment Outcome |
| title | Waiting Time from Diagnosis to Treatment has no Impact on Survival in Patients with Esophageal Cancer |
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