Evaluation of tolerability and efficacy of irreversible electroporation (IRE) in treatment of Child-Pugh B (7/8) hepatocellular carcinoma (HCC)
Abstract Introduction Few studies have assessed the tolerability and efficacy of irreversible electroporation (IRE) in the treatment of Child-Pugh B (7/8) patients with hepatocellular carcinoma (HCC). Based on its mechanism of action, we hypothesized that IRE would be superior to microwave (MW) abla...
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| creator | Bhutiani, Neal Philips, Prejesh Scoggins, Charles R McMasters, Kelly M Potts, Melissa H Martin, Robert C.G |
| description | Abstract Introduction Few studies have assessed the tolerability and efficacy of irreversible electroporation (IRE) in the treatment of Child-Pugh B (7/8) patients with hepatocellular carcinoma (HCC). Based on its mechanism of action, we hypothesized that IRE would be superior to microwave (MW) ablation and compared the liver tolerance and ablation success rates of these therapies in Child-Pugh B patients with HCC. Methods 55 patients with Child-Pugh B (7/8) HCC were treated with either MW ablation (n = 25) or IRE (n = 30). Tolerance and ablation success were evaluated at 30 and 90 days and 90 days and 6 months, respectively. Tolerance was defined as stable liver function and absence of increased ascites or worsening portal hypertension. Ablation success was defined as tumor eradication on triple phase contrasted computed tomography (CT). Results Patients undergoing IRE had shorter length of stay (p = 0.05) and 90 day readmission rate (p = 0.03) than those undergoing MW ablation. Additionally, IRE was better tolerated than MW ablation at 30 and 90 days. IRE and MW ablation resulted in 6 month success rates of 97% and 100%. Conclusion Treatment of Child-Pugh B (7/8) HCC with IRE results in equivalent ablation success with improved liver tolerance compared with MW ablation and other ablative modalities. |
| doi_str_mv | 10.1016/j.hpb.2016.03.609 |
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Based on its mechanism of action, we hypothesized that IRE would be superior to microwave (MW) ablation and compared the liver tolerance and ablation success rates of these therapies in Child-Pugh B patients with HCC. Methods 55 patients with Child-Pugh B (7/8) HCC were treated with either MW ablation (n = 25) or IRE (n = 30). Tolerance and ablation success were evaluated at 30 and 90 days and 90 days and 6 months, respectively. Tolerance was defined as stable liver function and absence of increased ascites or worsening portal hypertension. Ablation success was defined as tumor eradication on triple phase contrasted computed tomography (CT). Results Patients undergoing IRE had shorter length of stay (p = 0.05) and 90 day readmission rate (p = 0.03) than those undergoing MW ablation. Additionally, IRE was better tolerated than MW ablation at 30 and 90 days. IRE and MW ablation resulted in 6 month success rates of 97% and 100%. Conclusion Treatment of Child-Pugh B (7/8) HCC with IRE results in equivalent ablation success with improved liver tolerance compared with MW ablation and other ablative modalities.</description><identifier>ISSN: 1365-182X</identifier><identifier>EISSN: 1477-2574</identifier><identifier>DOI: 10.1016/j.hpb.2016.03.609</identifier><identifier>PMID: 27346140</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Ablation Techniques - adverse effects ; Aged ; Aged, 80 and over ; Carcinoma, Hepatocellular - diagnostic imaging ; Carcinoma, Hepatocellular - pathology ; Carcinoma, Hepatocellular - surgery ; Electroporation ; Female ; Gastroenterology and Hepatology ; Humans ; Length of Stay ; Liver Neoplasms - diagnostic imaging ; Liver Neoplasms - pathology ; Liver Neoplasms - surgery ; Male ; Microwaves - adverse effects ; Microwaves - therapeutic use ; Middle Aged ; Original ; Patient Readmission ; Postoperative Complications - etiology ; Registries ; Risk Factors ; Time Factors ; Tomography, X-Ray Computed ; Treatment Outcome</subject><ispartof>HPB (Oxford, England), 2016-07, Vol.18 (7), p.593-599</ispartof><rights>International Hepato-Pancreato-Biliary Association Inc.</rights><rights>2016 International Hepato-Pancreato-Biliary Association Inc.</rights><rights>Copyright © 2016 International Hepato-Pancreato-Biliary Association Inc. Published by Elsevier Ltd. All rights reserved.</rights><rights>2016 International Hepato-Pancreato-Biliary Association Inc. Published by Elsevier Ltd. All rights reserved. 2016 International Hepato-Pancreato-Biliary Association Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c572t-8a26a5198c52bb3bb0dc528b47ba03301917c6fe78490026411df4bd137857fb3</citedby><cites>FETCH-LOGICAL-c572t-8a26a5198c52bb3bb0dc528b47ba03301917c6fe78490026411df4bd137857fb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4925804/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4925804/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27346140$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bhutiani, Neal</creatorcontrib><creatorcontrib>Philips, Prejesh</creatorcontrib><creatorcontrib>Scoggins, Charles R</creatorcontrib><creatorcontrib>McMasters, Kelly M</creatorcontrib><creatorcontrib>Potts, Melissa H</creatorcontrib><creatorcontrib>Martin, Robert C.G</creatorcontrib><title>Evaluation of tolerability and efficacy of irreversible electroporation (IRE) in treatment of Child-Pugh B (7/8) hepatocellular carcinoma (HCC)</title><title>HPB (Oxford, England)</title><addtitle>HPB (Oxford)</addtitle><description>Abstract Introduction Few studies have assessed the tolerability and efficacy of irreversible electroporation (IRE) in the treatment of Child-Pugh B (7/8) patients with hepatocellular carcinoma (HCC). Based on its mechanism of action, we hypothesized that IRE would be superior to microwave (MW) ablation and compared the liver tolerance and ablation success rates of these therapies in Child-Pugh B patients with HCC. Methods 55 patients with Child-Pugh B (7/8) HCC were treated with either MW ablation (n = 25) or IRE (n = 30). Tolerance and ablation success were evaluated at 30 and 90 days and 90 days and 6 months, respectively. Tolerance was defined as stable liver function and absence of increased ascites or worsening portal hypertension. Ablation success was defined as tumor eradication on triple phase contrasted computed tomography (CT). Results Patients undergoing IRE had shorter length of stay (p = 0.05) and 90 day readmission rate (p = 0.03) than those undergoing MW ablation. Additionally, IRE was better tolerated than MW ablation at 30 and 90 days. IRE and MW ablation resulted in 6 month success rates of 97% and 100%. Conclusion Treatment of Child-Pugh B (7/8) HCC with IRE results in equivalent ablation success with improved liver tolerance compared with MW ablation and other ablative modalities.</description><subject>Ablation Techniques - adverse effects</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Carcinoma, Hepatocellular - diagnostic imaging</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Carcinoma, Hepatocellular - surgery</subject><subject>Electroporation</subject><subject>Female</subject><subject>Gastroenterology and Hepatology</subject><subject>Humans</subject><subject>Length of Stay</subject><subject>Liver Neoplasms - diagnostic imaging</subject><subject>Liver Neoplasms - pathology</subject><subject>Liver Neoplasms - surgery</subject><subject>Male</subject><subject>Microwaves - adverse effects</subject><subject>Microwaves - therapeutic use</subject><subject>Middle Aged</subject><subject>Original</subject><subject>Patient Readmission</subject><subject>Postoperative Complications - etiology</subject><subject>Registries</subject><subject>Risk Factors</subject><subject>Time Factors</subject><subject>Tomography, X-Ray Computed</subject><subject>Treatment Outcome</subject><issn>1365-182X</issn><issn>1477-2574</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9Ul2L1DAULaK46-oP8EXyOPPQbj7apkVY0DK6CwuKH-BbSNLbbca0qUk7ML_Cv2zKrIv6IARy4Z5z7se5SfKS4IxgUl7us35SGY1hhllW4vpRck5yzlNa8PxxjFlZpKSi386SZyHsMaaRVj9NzihneUlyfJ783B2kXeRs3Ihch2ZnwUtlrJmPSI4tgq4zWurjmjTewwF8MMoCAgt69m5y_kTe3HzabZEZ0exBzgOM80ppemPb9ONy16O3aMMvqy3qYZKz02DtYqVHWnptRjdItLlumu3z5EknbYAX9_9F8vXd7ktznd5-eH_TvLlNdcHpnFaSlrIgdaULqhRTCrcxqlTOlcSMxSkJ12UHvMrrOHaZE9J2uWoJ41XBO8UukquT7rSoAVod-_XSismbQfqjcNKIvzOj6cWdO4i8pkWF8yiwuRfw7scCYRaDCetUcgS3BEEqjAnDNa0jlJyg2rsQPHQPZQgWq5FiL6KRYjVSYCaikZHz6s_-Hhi_nYuA1ycAxC0dDHgRtIFRQ2t8dEa0zvxX_uoftrZmjE7b73CEsHeLH-P6BRGBCiw-r5e0HhIpWXy4ZL8AtOzENw</recordid><startdate>20160701</startdate><enddate>20160701</enddate><creator>Bhutiani, Neal</creator><creator>Philips, Prejesh</creator><creator>Scoggins, Charles R</creator><creator>McMasters, Kelly M</creator><creator>Potts, Melissa H</creator><creator>Martin, Robert C.G</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160701</creationdate><title>Evaluation of tolerability and efficacy of irreversible electroporation (IRE) in treatment of Child-Pugh B (7/8) hepatocellular carcinoma (HCC)</title><author>Bhutiani, Neal ; Philips, Prejesh ; Scoggins, Charles R ; McMasters, Kelly M ; Potts, Melissa H ; Martin, Robert C.G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c572t-8a26a5198c52bb3bb0dc528b47ba03301917c6fe78490026411df4bd137857fb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Ablation Techniques - adverse effects</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Carcinoma, Hepatocellular - diagnostic imaging</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>Carcinoma, Hepatocellular - surgery</topic><topic>Electroporation</topic><topic>Female</topic><topic>Gastroenterology and Hepatology</topic><topic>Humans</topic><topic>Length of Stay</topic><topic>Liver Neoplasms - diagnostic imaging</topic><topic>Liver Neoplasms - pathology</topic><topic>Liver Neoplasms - surgery</topic><topic>Male</topic><topic>Microwaves - adverse effects</topic><topic>Microwaves - therapeutic use</topic><topic>Middle Aged</topic><topic>Original</topic><topic>Patient Readmission</topic><topic>Postoperative Complications - etiology</topic><topic>Registries</topic><topic>Risk Factors</topic><topic>Time Factors</topic><topic>Tomography, X-Ray Computed</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bhutiani, Neal</creatorcontrib><creatorcontrib>Philips, Prejesh</creatorcontrib><creatorcontrib>Scoggins, Charles R</creatorcontrib><creatorcontrib>McMasters, Kelly M</creatorcontrib><creatorcontrib>Potts, Melissa H</creatorcontrib><creatorcontrib>Martin, Robert C.G</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>HPB (Oxford, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bhutiani, Neal</au><au>Philips, Prejesh</au><au>Scoggins, Charles R</au><au>McMasters, Kelly M</au><au>Potts, Melissa H</au><au>Martin, Robert C.G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of tolerability and efficacy of irreversible electroporation (IRE) in treatment of Child-Pugh B (7/8) hepatocellular carcinoma (HCC)</atitle><jtitle>HPB (Oxford, England)</jtitle><addtitle>HPB (Oxford)</addtitle><date>2016-07-01</date><risdate>2016</risdate><volume>18</volume><issue>7</issue><spage>593</spage><epage>599</epage><pages>593-599</pages><issn>1365-182X</issn><eissn>1477-2574</eissn><abstract>Abstract Introduction Few studies have assessed the tolerability and efficacy of irreversible electroporation (IRE) in the treatment of Child-Pugh B (7/8) patients with hepatocellular carcinoma (HCC). Based on its mechanism of action, we hypothesized that IRE would be superior to microwave (MW) ablation and compared the liver tolerance and ablation success rates of these therapies in Child-Pugh B patients with HCC. Methods 55 patients with Child-Pugh B (7/8) HCC were treated with either MW ablation (n = 25) or IRE (n = 30). Tolerance and ablation success were evaluated at 30 and 90 days and 90 days and 6 months, respectively. Tolerance was defined as stable liver function and absence of increased ascites or worsening portal hypertension. Ablation success was defined as tumor eradication on triple phase contrasted computed tomography (CT). Results Patients undergoing IRE had shorter length of stay (p = 0.05) and 90 day readmission rate (p = 0.03) than those undergoing MW ablation. Additionally, IRE was better tolerated than MW ablation at 30 and 90 days. IRE and MW ablation resulted in 6 month success rates of 97% and 100%. Conclusion Treatment of Child-Pugh B (7/8) HCC with IRE results in equivalent ablation success with improved liver tolerance compared with MW ablation and other ablative modalities.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>27346140</pmid><doi>10.1016/j.hpb.2016.03.609</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Ablation Techniques - adverse effects Aged Aged, 80 and over Carcinoma, Hepatocellular - diagnostic imaging Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - surgery Electroporation Female Gastroenterology and Hepatology Humans Length of Stay Liver Neoplasms - diagnostic imaging Liver Neoplasms - pathology Liver Neoplasms - surgery Male Microwaves - adverse effects Microwaves - therapeutic use Middle Aged Original Patient Readmission Postoperative Complications - etiology Registries Risk Factors Time Factors Tomography, X-Ray Computed Treatment Outcome |
| title | Evaluation of tolerability and efficacy of irreversible electroporation (IRE) in treatment of Child-Pugh B (7/8) hepatocellular carcinoma (HCC) |
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