Synergistic effect of low-dose cucurbitacin B and low-dose methotrexate for treatment of human osteosarcoma

Abstract We investigated the use of cucurbitacin B, a plant-derived tetracyclic triterpenoid, as a single agent or in combination with methotrexate (MTX) for human osteosarcoma (OS) treatment. Cucurbitacin B showed antiproliferative activity against seven human OS cell lines in vitro accompanying G2...

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Veröffentlicht in:	Cancer letters 2011-07, Vol.306 (2), p.161-170
Hauptverfasser:	Lee, Dhong Hyun, Thoennissen, Nils H, Goff, Catherine, Iwanski, Gabriela B, Forscher, Charles, Doan, Ngan B, Said, Jonathan W, Phillip Koeffler, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimetabolites, Antineoplastic - therapeutic use Apoptosis Apoptosis - drug effects Blotting, Western body weight Bone cancer Bone Neoplasms - drug therapy Bone Neoplasms - metabolism Bone Neoplasms - pathology Cancer therapies cell cycle Cell Cycle - drug effects Cell growth Cell Proliferation - drug effects Chemical compounds Chemotherapy Cucurbitacin B Dose-Response Relationship, Drug Drug dosages Drug Synergism Female Hematology, Oncology and Palliative Medicine Humans Immunoenzyme Techniques Kinases Life sciences Methotrexate Methotrexate - therapeutic use Mice Mice, Nude Mitogen-Activated Protein Kinases - metabolism Osteosarcoma Osteosarcoma - drug therapy Osteosarcoma - metabolism Osteosarcoma - pathology Phosphatidylinositol 3-Kinase - metabolism Phosphorylation Phosphorylation - drug effects proteins Proto-Oncogene Proteins c-akt - metabolism Studies Synergism therapeutics TOR Serine-Threonine Kinases - metabolism Toxicity Triterpenes - therapeutic use Tumor Cells, Cultured Xenograft Xenograft Model Antitumor Assays
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