Disruption of CCL20-CCR6 interaction inhibits metastasis of advanced cutaneous T-cell lymphoma

We recently demonstrated that upregulation of a chemokine receptor CCR6 and its ligand CCL20 led to metastasis of advanced cutaneous T-cell lymphoma (CTCL) cells, suggesting the involvement of CCL20-CCR6 interaction in initiating CTCL cell metastasis. In this study, we determined whether this intera...

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Veröffentlicht in:	Oncotarget 2016-03, Vol.7 (12), p.13563-13574
Hauptverfasser:	Ikeda, Sho, Kitadate, Akihiro, Ito, Mitsugu, Abe, Fumito, Nara, Miho, Watanabe, Atsushi, Takahashi, Naoto, Miyagaki, Tomomitsu, Sugaya, Makoto, Tagawa, Hiroyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Animals Apoptosis Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Cell Movement Cell Proliferation Chemokine CCL20 - antagonists & inhibitors Chemokine CCL20 - genetics Chemokine CCL20 - metabolism Female Humans Lymphoma, T-Cell, Cutaneous - genetics Lymphoma, T-Cell, Cutaneous - metabolism Lymphoma, T-Cell, Cutaneous - pathology Male Mice Mice, Inbred NOD Mice, SCID Middle Aged Neoplasm Metastasis Neoplasm Staging Prognosis Receptors, CCR6 - antagonists & inhibitors Receptors, CCR6 - genetics Receptors, CCR6 - metabolism Research Paper Skin Neoplasms - genetics Skin Neoplasms - metabolism Skin Neoplasms - secondary STAT3 Transcription Factor - antagonists & inhibitors STAT3 Transcription Factor - genetics STAT3 Transcription Factor - metabolism Tumor Cells, Cultured Xenograft Model Antitumor Assays
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