Recreational physical activity and ovarian cancer risk in African American women
The literature on recreational physical activity (RPA) and ovarian cancer risk is inconclusive and most studies of RPA and ovarian cancer have been conducted in white populations. This study is the first to investigate the association between RPA and ovarian cancer in an exclusively African American...
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| Veröffentlicht in: | Cancer medicine (Malden, MA) MA), 2016-06, Vol.5 (6), p.1319-1327 |
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| creator | Abbott, Sarah E. Bandera, Elisa V. Qin, Bo Peres, Lauren C. Moorman, Patricia G. Barnholtz‐Sloan, Jill Schwartz, Ann G. Funkhouser, Ellen Peters, Edward S. Cote, Michele L. Alberg, Anthony J. Terry, Paul Bondy, Melissa Paddock, Lisa E. Crankshaw, Sydnee Wang, Frances Camacho, Fabian Schildkraut, Joellen M. |
| description | The literature on recreational physical activity (RPA) and ovarian cancer risk is inconclusive and most studies of RPA and ovarian cancer have been conducted in white populations. This study is the first to investigate the association between RPA and ovarian cancer in an exclusively African American (AA) population. We analyzed data from an ongoing U.S. population‐based, case–control study of AA women, which included 393 women recently diagnosed with invasive epithelial ovarian cancer (IEOC) and 611 controls. A baseline interview assessed RPA frequency, intensity, and duration. Each RPA intensity was assigned a metabolic equivalent of task (MET) value and MET‐min/week were calculated. Unconditional multivariable logistic regression was performed to investigate associations between RPA and IEOC risk. Compared with sedentary women, predominantly mild intensity RPA was significantly inversely associated with IEOC risk for women reporting above median (>297) MET‐min/week (odds ratio [OR] = 0.52; 95% confidence interval [CI]: 0.34, 0.78) and nonsignificantly for 540) MET‐min/week (OR = 1.51; 95% CI: 1.03, 2.23). Predominantly strenuous intensity RPA was nonsignificantly associated with lower IEOC risk for women reporting above median (>1800) MET‐min/week (OR = 0.72; 95% CI: 0.33, 1.57). The inverse associations for mild and strenuous intensity RPA were most pronounced in obese women (body mass index >30 kg/m2). The findings that mild and strenuous RPA may reduce the risk of IEOC particularly among obese women are difficult to reconcile with the increased risk observed for moderate RPA. Further research is warranted to determine whether these findings are genuine and, if so, their mechanistic basis.
This is the first study of recreational physical activity (RPA) and ovarian cancer in an exclusively African American population, who have a higher prevalence of obesity and poorer ovarian cancer survival compared with whites. We found that mild and strenuous intensity RPA may be associated with reduced ovarian cancer risk. Further, our data suggest that these associations may be more pronounced in obese women. |
| doi_str_mv | 10.1002/cam4.677 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4924390</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2290041134</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4387-6667b4f7ce5748a1feb8938ae4db0119c7da0b6cb11ab99c5b75f6a8b3df00b63</originalsourceid><addsrcrecordid>eNp1kU1rGzEQhkVpqU0SyC8IC730som-Vtq9FIxpm4BDSmnOYqTVJkp3JUda2_jfV8aJcQOZywzMw8MwL0LnBF8SjOmVgYFfCik_oCnFvCqlYPzj0TxBZyk94VwSUyHJZzShoqGMMzpFv35bEy2MLnjoi-XjNjmTBzCjW7txW4Bvi7CG6MAXBryxsYgu_S2cL2ZdzGzug90PmzBYf4o-ddAne_bST9D9j-9_5tfl4u7nzXy2KA1ntSyFEFLzThpbSV4D6ayuG1aD5a3GhDRGtoC1MJoQ0E1jKi2rTkCtWdvhvGAn6Nveu1zpwbbG-jFCr5bRDRC3KoBT_2-8e1QPYa14QzlrcBZ8fRHE8LyyaVSDS8b2PXgbVkmRGmOOGatIRr-8QZ_CKuaHJUVpkzFC8jcPQhNDStF2h2MIVruk1C4plZPK6MXx8QfwNZcMlHtg43q7fVek5rNbvhP-A_dRnS0</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2290041134</pqid></control><display><type>article</type><title>Recreational physical activity and ovarian cancer risk in African American women</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Wiley-Blackwell Open Access Titles</source><source>PubMed Central</source><creator>Abbott, Sarah E. ; Bandera, Elisa V. ; Qin, Bo ; Peres, Lauren C. ; Moorman, Patricia G. ; Barnholtz‐Sloan, Jill ; Schwartz, Ann G. ; Funkhouser, Ellen ; Peters, Edward S. ; Cote, Michele L. ; Alberg, Anthony J. ; Terry, Paul ; Bondy, Melissa ; Paddock, Lisa E. ; Crankshaw, Sydnee ; Wang, Frances ; Camacho, Fabian ; Schildkraut, Joellen M.</creator><creatorcontrib>Abbott, Sarah E. ; Bandera, Elisa V. ; Qin, Bo ; Peres, Lauren C. ; Moorman, Patricia G. ; Barnholtz‐Sloan, Jill ; Schwartz, Ann G. ; Funkhouser, Ellen ; Peters, Edward S. ; Cote, Michele L. ; Alberg, Anthony J. ; Terry, Paul ; Bondy, Melissa ; Paddock, Lisa E. ; Crankshaw, Sydnee ; Wang, Frances ; Camacho, Fabian ; Schildkraut, Joellen M.</creatorcontrib><description>The literature on recreational physical activity (RPA) and ovarian cancer risk is inconclusive and most studies of RPA and ovarian cancer have been conducted in white populations. This study is the first to investigate the association between RPA and ovarian cancer in an exclusively African American (AA) population. We analyzed data from an ongoing U.S. population‐based, case–control study of AA women, which included 393 women recently diagnosed with invasive epithelial ovarian cancer (IEOC) and 611 controls. A baseline interview assessed RPA frequency, intensity, and duration. Each RPA intensity was assigned a metabolic equivalent of task (MET) value and MET‐min/week were calculated. Unconditional multivariable logistic regression was performed to investigate associations between RPA and IEOC risk. Compared with sedentary women, predominantly mild intensity RPA was significantly inversely associated with IEOC risk for women reporting above median (>297) MET‐min/week (odds ratio [OR] = 0.52; 95% confidence interval [CI]: 0.34, 0.78) and nonsignificantly for <297 MET‐min/week (OR = 0.71; 95% CI: 0.44, 1.12). Predominantly moderate intensity RPA was associated with significantly increased risk for women reporting above median (>540) MET‐min/week (OR = 1.51; 95% CI: 1.03, 2.23). Predominantly strenuous intensity RPA was nonsignificantly associated with lower IEOC risk for women reporting above median (>1800) MET‐min/week (OR = 0.72; 95% CI: 0.33, 1.57). The inverse associations for mild and strenuous intensity RPA were most pronounced in obese women (body mass index >30 kg/m2). The findings that mild and strenuous RPA may reduce the risk of IEOC particularly among obese women are difficult to reconcile with the increased risk observed for moderate RPA. Further research is warranted to determine whether these findings are genuine and, if so, their mechanistic basis.
This is the first study of recreational physical activity (RPA) and ovarian cancer in an exclusively African American population, who have a higher prevalence of obesity and poorer ovarian cancer survival compared with whites. We found that mild and strenuous intensity RPA may be associated with reduced ovarian cancer risk. Further, our data suggest that these associations may be more pronounced in obese women.</description><identifier>ISSN: 2045-7634</identifier><identifier>EISSN: 2045-7634</identifier><identifier>DOI: 10.1002/cam4.677</identifier><identifier>PMID: 26923432</identifier><language>eng</language><publisher>United States: John Wiley & Sons, Inc</publisher><subject>Adult ; African American ; African Americans ; Aged ; Bias ; Body mass index ; Cancer Prevention ; Case-Control Studies ; Comorbidity ; Epidemiology ; Exercise ; Exercise intensity ; Family medical history ; Female ; Health risk assessment ; Humans ; Invasiveness ; Metabolism ; Middle Aged ; Motor Activity ; Odds Ratio ; Original Research ; Ovarian cancer ; Ovarian Neoplasms - epidemiology ; Physical activity ; Physical fitness ; Population ; Population studies ; Population Surveillance ; Questionnaires ; Recreation ; Risk ; Studies ; United States - epidemiology ; Young Adult</subject><ispartof>Cancer medicine (Malden, MA), 2016-06, Vol.5 (6), p.1319-1327</ispartof><rights>2016 The Authors. published by John Wiley & Sons Ltd.</rights><rights>2016 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.</rights><rights>2016. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4387-6667b4f7ce5748a1feb8938ae4db0119c7da0b6cb11ab99c5b75f6a8b3df00b63</citedby><cites>FETCH-LOGICAL-c4387-6667b4f7ce5748a1feb8938ae4db0119c7da0b6cb11ab99c5b75f6a8b3df00b63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924390/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924390/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,1412,11543,27905,27906,45555,45556,46033,46457,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26923432$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abbott, Sarah E.</creatorcontrib><creatorcontrib>Bandera, Elisa V.</creatorcontrib><creatorcontrib>Qin, Bo</creatorcontrib><creatorcontrib>Peres, Lauren C.</creatorcontrib><creatorcontrib>Moorman, Patricia G.</creatorcontrib><creatorcontrib>Barnholtz‐Sloan, Jill</creatorcontrib><creatorcontrib>Schwartz, Ann G.</creatorcontrib><creatorcontrib>Funkhouser, Ellen</creatorcontrib><creatorcontrib>Peters, Edward S.</creatorcontrib><creatorcontrib>Cote, Michele L.</creatorcontrib><creatorcontrib>Alberg, Anthony J.</creatorcontrib><creatorcontrib>Terry, Paul</creatorcontrib><creatorcontrib>Bondy, Melissa</creatorcontrib><creatorcontrib>Paddock, Lisa E.</creatorcontrib><creatorcontrib>Crankshaw, Sydnee</creatorcontrib><creatorcontrib>Wang, Frances</creatorcontrib><creatorcontrib>Camacho, Fabian</creatorcontrib><creatorcontrib>Schildkraut, Joellen M.</creatorcontrib><title>Recreational physical activity and ovarian cancer risk in African American women</title><title>Cancer medicine (Malden, MA)</title><addtitle>Cancer Med</addtitle><description>The literature on recreational physical activity (RPA) and ovarian cancer risk is inconclusive and most studies of RPA and ovarian cancer have been conducted in white populations. This study is the first to investigate the association between RPA and ovarian cancer in an exclusively African American (AA) population. We analyzed data from an ongoing U.S. population‐based, case–control study of AA women, which included 393 women recently diagnosed with invasive epithelial ovarian cancer (IEOC) and 611 controls. A baseline interview assessed RPA frequency, intensity, and duration. Each RPA intensity was assigned a metabolic equivalent of task (MET) value and MET‐min/week were calculated. Unconditional multivariable logistic regression was performed to investigate associations between RPA and IEOC risk. Compared with sedentary women, predominantly mild intensity RPA was significantly inversely associated with IEOC risk for women reporting above median (>297) MET‐min/week (odds ratio [OR] = 0.52; 95% confidence interval [CI]: 0.34, 0.78) and nonsignificantly for <297 MET‐min/week (OR = 0.71; 95% CI: 0.44, 1.12). Predominantly moderate intensity RPA was associated with significantly increased risk for women reporting above median (>540) MET‐min/week (OR = 1.51; 95% CI: 1.03, 2.23). Predominantly strenuous intensity RPA was nonsignificantly associated with lower IEOC risk for women reporting above median (>1800) MET‐min/week (OR = 0.72; 95% CI: 0.33, 1.57). The inverse associations for mild and strenuous intensity RPA were most pronounced in obese women (body mass index >30 kg/m2). The findings that mild and strenuous RPA may reduce the risk of IEOC particularly among obese women are difficult to reconcile with the increased risk observed for moderate RPA. Further research is warranted to determine whether these findings are genuine and, if so, their mechanistic basis.
This is the first study of recreational physical activity (RPA) and ovarian cancer in an exclusively African American population, who have a higher prevalence of obesity and poorer ovarian cancer survival compared with whites. We found that mild and strenuous intensity RPA may be associated with reduced ovarian cancer risk. Further, our data suggest that these associations may be more pronounced in obese women.</description><subject>Adult</subject><subject>African American</subject><subject>African Americans</subject><subject>Aged</subject><subject>Bias</subject><subject>Body mass index</subject><subject>Cancer Prevention</subject><subject>Case-Control Studies</subject><subject>Comorbidity</subject><subject>Epidemiology</subject><subject>Exercise</subject><subject>Exercise intensity</subject><subject>Family medical history</subject><subject>Female</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Invasiveness</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Motor Activity</subject><subject>Odds Ratio</subject><subject>Original Research</subject><subject>Ovarian cancer</subject><subject>Ovarian Neoplasms - epidemiology</subject><subject>Physical activity</subject><subject>Physical fitness</subject><subject>Population</subject><subject>Population studies</subject><subject>Population Surveillance</subject><subject>Questionnaires</subject><subject>Recreation</subject><subject>Risk</subject><subject>Studies</subject><subject>United States - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer medicine (Malden, MA)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abbott, Sarah E.</au><au>Bandera, Elisa V.</au><au>Qin, Bo</au><au>Peres, Lauren C.</au><au>Moorman, Patricia G.</au><au>Barnholtz‐Sloan, Jill</au><au>Schwartz, Ann G.</au><au>Funkhouser, Ellen</au><au>Peters, Edward S.</au><au>Cote, Michele L.</au><au>Alberg, Anthony J.</au><au>Terry, Paul</au><au>Bondy, Melissa</au><au>Paddock, Lisa E.</au><au>Crankshaw, Sydnee</au><au>Wang, Frances</au><au>Camacho, Fabian</au><au>Schildkraut, Joellen M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Recreational physical activity and ovarian cancer risk in African American women</atitle><jtitle>Cancer medicine (Malden, MA)</jtitle><addtitle>Cancer Med</addtitle><date>2016-06</date><risdate>2016</risdate><volume>5</volume><issue>6</issue><spage>1319</spage><epage>1327</epage><pages>1319-1327</pages><issn>2045-7634</issn><eissn>2045-7634</eissn><abstract>The literature on recreational physical activity (RPA) and ovarian cancer risk is inconclusive and most studies of RPA and ovarian cancer have been conducted in white populations. This study is the first to investigate the association between RPA and ovarian cancer in an exclusively African American (AA) population. We analyzed data from an ongoing U.S. population‐based, case–control study of AA women, which included 393 women recently diagnosed with invasive epithelial ovarian cancer (IEOC) and 611 controls. A baseline interview assessed RPA frequency, intensity, and duration. Each RPA intensity was assigned a metabolic equivalent of task (MET) value and MET‐min/week were calculated. Unconditional multivariable logistic regression was performed to investigate associations between RPA and IEOC risk. Compared with sedentary women, predominantly mild intensity RPA was significantly inversely associated with IEOC risk for women reporting above median (>297) MET‐min/week (odds ratio [OR] = 0.52; 95% confidence interval [CI]: 0.34, 0.78) and nonsignificantly for <297 MET‐min/week (OR = 0.71; 95% CI: 0.44, 1.12). Predominantly moderate intensity RPA was associated with significantly increased risk for women reporting above median (>540) MET‐min/week (OR = 1.51; 95% CI: 1.03, 2.23). Predominantly strenuous intensity RPA was nonsignificantly associated with lower IEOC risk for women reporting above median (>1800) MET‐min/week (OR = 0.72; 95% CI: 0.33, 1.57). The inverse associations for mild and strenuous intensity RPA were most pronounced in obese women (body mass index >30 kg/m2). The findings that mild and strenuous RPA may reduce the risk of IEOC particularly among obese women are difficult to reconcile with the increased risk observed for moderate RPA. Further research is warranted to determine whether these findings are genuine and, if so, their mechanistic basis.
This is the first study of recreational physical activity (RPA) and ovarian cancer in an exclusively African American population, who have a higher prevalence of obesity and poorer ovarian cancer survival compared with whites. We found that mild and strenuous intensity RPA may be associated with reduced ovarian cancer risk. Further, our data suggest that these associations may be more pronounced in obese women.</abstract><cop>United States</cop><pub>John Wiley & Sons, Inc</pub><pmid>26923432</pmid><doi>10.1002/cam4.677</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 2045-7634 |
| ispartof | Cancer medicine (Malden, MA), 2016-06, Vol.5 (6), p.1319-1327 |
| issn | 2045-7634 2045-7634 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley-Blackwell Open Access Titles; PubMed Central |
| subjects | Adult African American African Americans Aged Bias Body mass index Cancer Prevention Case-Control Studies Comorbidity Epidemiology Exercise Exercise intensity Family medical history Female Health risk assessment Humans Invasiveness Metabolism Middle Aged Motor Activity Odds Ratio Original Research Ovarian cancer Ovarian Neoplasms - epidemiology Physical activity Physical fitness Population Population studies Population Surveillance Questionnaires Recreation Risk Studies United States - epidemiology Young Adult |
| title | Recreational physical activity and ovarian cancer risk in African American women |
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