MiR‐24 enhances radiosensitivity in nasopharyngeal carcinoma by targeting SP1
Radioresistance remains a major problem in the treatment of patients suffering from nasopharyngeal carcinoma (NPC). A better understanding of the mechanisms of radioresistance may generate new strategies to improve NPC patients' responses to therapy. This study was designed to investigate the e...
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| Veröffentlicht in: | Cancer medicine (Malden, MA) MA), 2016-06, Vol.5 (6), p.1163-1173 |
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| creator | Kang, Min Xiao, Jingjian Wang, Jun Zhou, Pingting Wei, Tingting Zhao, Tingting Wang, Rensheng |
| description | Radioresistance remains a major problem in the treatment of patients suffering from nasopharyngeal carcinoma (NPC). A better understanding of the mechanisms of radioresistance may generate new strategies to improve NPC patients' responses to therapy. This study was designed to investigate the effect of microRNA on the radiosensitivity of NPC cells. A microRNA microarray indicated that miR‐24 was downregulated in NPC cell lines and tissues. Furthermore, cell proliferation was suppressed and radiosensitivity increased when miR‐24 was ectopically expressed in NPC cells. Specificity protein 1 (SP1) was additionally verified as a direct functional target of miR‐24, which was found to be involved in cell viability as well as the radiosensitivity of NPC cells. In conclusion, the results of this study suggest that the miR‐24/SP1 pathway contributed to the reduction in radioresistance in human NPC and that it may thus represent a therapeutic target.
This study aimed to investigate the effect of microRNA (miR)‐24 on the radiosensitivity of NPC cells. The results of this study suggested that the identified miR‐24/Sp1 pathway contributed to the elucidation of the mechanisms of radiosensitivity in human NPC and that it may represent a potential therapeutic target. |
| doi_str_mv | 10.1002/cam4.660 |
| format | Article |
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This study aimed to investigate the effect of microRNA (miR)‐24 on the radiosensitivity of NPC cells. The results of this study suggested that the identified miR‐24/Sp1 pathway contributed to the elucidation of the mechanisms of radiosensitivity in human NPC and that it may represent a potential therapeutic target.</description><identifier>ISSN: 2045-7634</identifier><identifier>EISSN: 2045-7634</identifier><identifier>DOI: 10.1002/cam4.660</identifier><identifier>PMID: 26922862</identifier><language>eng</language><publisher>United States: John Wiley and Sons Inc</publisher><subject>Adult ; Aged ; Animals ; Cancer Biology ; Carcinoma ; Cell Line, Tumor ; Cell Survival - genetics ; Cell Survival - radiation effects ; Disease Models, Animal ; Female ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Mice ; MicroRNAs - chemistry ; MicroRNAs - genetics ; Middle Aged ; miR‐24 ; Nasopharyngeal Carcinoma ; Nasopharyngeal Neoplasms - genetics ; Nasopharyngeal Neoplasms - pathology ; Nasopharyngeal Neoplasms - radiotherapy ; Original Research ; Radiation Tolerance - genetics ; radiosensitivity ; RNA Interference ; RNA, Messenger - chemistry ; RNA, Messenger - genetics ; SP1 ; Sp1 Transcription Factor - genetics ; Xenograft Model Antitumor Assays ; Young Adult</subject><ispartof>Cancer medicine (Malden, MA), 2016-06, Vol.5 (6), p.1163-1173</ispartof><rights>2016 The Authors. published by John Wiley & Sons Ltd.</rights><rights>2016 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924375/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924375/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,1411,11542,27903,27904,45553,45554,46030,46454,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26922862$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kang, Min</creatorcontrib><creatorcontrib>Xiao, Jingjian</creatorcontrib><creatorcontrib>Wang, Jun</creatorcontrib><creatorcontrib>Zhou, Pingting</creatorcontrib><creatorcontrib>Wei, Tingting</creatorcontrib><creatorcontrib>Zhao, Tingting</creatorcontrib><creatorcontrib>Wang, Rensheng</creatorcontrib><title>MiR‐24 enhances radiosensitivity in nasopharyngeal carcinoma by targeting SP1</title><title>Cancer medicine (Malden, MA)</title><addtitle>Cancer Med</addtitle><description>Radioresistance remains a major problem in the treatment of patients suffering from nasopharyngeal carcinoma (NPC). A better understanding of the mechanisms of radioresistance may generate new strategies to improve NPC patients' responses to therapy. This study was designed to investigate the effect of microRNA on the radiosensitivity of NPC cells. A microRNA microarray indicated that miR‐24 was downregulated in NPC cell lines and tissues. Furthermore, cell proliferation was suppressed and radiosensitivity increased when miR‐24 was ectopically expressed in NPC cells. Specificity protein 1 (SP1) was additionally verified as a direct functional target of miR‐24, which was found to be involved in cell viability as well as the radiosensitivity of NPC cells. In conclusion, the results of this study suggest that the miR‐24/SP1 pathway contributed to the reduction in radioresistance in human NPC and that it may thus represent a therapeutic target.
This study aimed to investigate the effect of microRNA (miR)‐24 on the radiosensitivity of NPC cells. The results of this study suggested that the identified miR‐24/Sp1 pathway contributed to the elucidation of the mechanisms of radiosensitivity in human NPC and that it may represent a potential therapeutic target.</description><subject>Adult</subject><subject>Aged</subject><subject>Animals</subject><subject>Cancer Biology</subject><subject>Carcinoma</subject><subject>Cell Line, Tumor</subject><subject>Cell Survival - genetics</subject><subject>Cell Survival - radiation effects</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>Gene Expression Profiling</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Male</subject><subject>Mice</subject><subject>MicroRNAs - chemistry</subject><subject>MicroRNAs - genetics</subject><subject>Middle Aged</subject><subject>miR‐24</subject><subject>Nasopharyngeal Carcinoma</subject><subject>Nasopharyngeal Neoplasms - genetics</subject><subject>Nasopharyngeal Neoplasms - pathology</subject><subject>Nasopharyngeal Neoplasms - radiotherapy</subject><subject>Original Research</subject><subject>Radiation Tolerance - genetics</subject><subject>radiosensitivity</subject><subject>RNA Interference</subject><subject>RNA, Messenger - chemistry</subject><subject>RNA, Messenger - genetics</subject><subject>SP1</subject><subject>Sp1 Transcription Factor - genetics</subject><subject>Xenograft Model Antitumor Assays</subject><subject>Young Adult</subject><issn>2045-7634</issn><issn>2045-7634</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><recordid>eNpVUctqwzAQFKWlCWmgX1B87MXpSpYt-1IIoS9ISOnjLGRZdhRsObWcFN_6Cf3GfkkVkoZ0WdiFHWaGHYQuMYwwALmRoqKjKIIT1CdAQ59FAT092ntoaO0SXDEgEcPnqEeihJA4In00n-mXn69vQj1lFsJIZb1GZLq2yljd6o1uO08bzwhbrxai6UyhROlJ0Uht6kp4aee1oilUq03hvT7jC3SWi9Kq4X4O0Pv93dvk0Z_OH54m46m_pEDBxyATlUtJZcwkkYQGcZ4kGeCMxIyqEBgL8wxUHMYQiSCAPE1SBQnJBXYdBQN0u-NdrdNKZVKZthElXzW6ci55LTT_fzF6wYt6w2nixFjoCK73BE39sVa25ZW2UpWlMKpeW45jcEYppsxBr461DiJ_X3QAfwf41KXqDncMfBsQ3wbEXUB8Mp5RN4NflRqDqQ</recordid><startdate>201606</startdate><enddate>201606</enddate><creator>Kang, Min</creator><creator>Xiao, Jingjian</creator><creator>Wang, Jun</creator><creator>Zhou, Pingting</creator><creator>Wei, Tingting</creator><creator>Zhao, Tingting</creator><creator>Wang, Rensheng</creator><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201606</creationdate><title>MiR‐24 enhances radiosensitivity in nasopharyngeal carcinoma by targeting SP1</title><author>Kang, Min ; Xiao, Jingjian ; Wang, Jun ; Zhou, Pingting ; Wei, Tingting ; Zhao, Tingting ; Wang, Rensheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j4040-10c9efcc4c87c2c2438f99d01d2874e50775fd0e85806a330fb9be092fa1fa163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Animals</topic><topic>Cancer Biology</topic><topic>Carcinoma</topic><topic>Cell Line, Tumor</topic><topic>Cell Survival - genetics</topic><topic>Cell Survival - radiation effects</topic><topic>Disease Models, Animal</topic><topic>Female</topic><topic>Gene Expression Profiling</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Male</topic><topic>Mice</topic><topic>MicroRNAs - chemistry</topic><topic>MicroRNAs - genetics</topic><topic>Middle Aged</topic><topic>miR‐24</topic><topic>Nasopharyngeal Carcinoma</topic><topic>Nasopharyngeal Neoplasms - genetics</topic><topic>Nasopharyngeal Neoplasms - pathology</topic><topic>Nasopharyngeal Neoplasms - radiotherapy</topic><topic>Original Research</topic><topic>Radiation Tolerance - genetics</topic><topic>radiosensitivity</topic><topic>RNA Interference</topic><topic>RNA, Messenger - chemistry</topic><topic>RNA, Messenger - genetics</topic><topic>SP1</topic><topic>Sp1 Transcription Factor - genetics</topic><topic>Xenograft Model Antitumor Assays</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kang, Min</creatorcontrib><creatorcontrib>Xiao, Jingjian</creatorcontrib><creatorcontrib>Wang, Jun</creatorcontrib><creatorcontrib>Zhou, Pingting</creatorcontrib><creatorcontrib>Wei, Tingting</creatorcontrib><creatorcontrib>Zhao, Tingting</creatorcontrib><creatorcontrib>Wang, Rensheng</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer medicine (Malden, MA)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kang, Min</au><au>Xiao, Jingjian</au><au>Wang, Jun</au><au>Zhou, Pingting</au><au>Wei, Tingting</au><au>Zhao, Tingting</au><au>Wang, Rensheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MiR‐24 enhances radiosensitivity in nasopharyngeal carcinoma by targeting SP1</atitle><jtitle>Cancer medicine (Malden, MA)</jtitle><addtitle>Cancer Med</addtitle><date>2016-06</date><risdate>2016</risdate><volume>5</volume><issue>6</issue><spage>1163</spage><epage>1173</epage><pages>1163-1173</pages><issn>2045-7634</issn><eissn>2045-7634</eissn><abstract>Radioresistance remains a major problem in the treatment of patients suffering from nasopharyngeal carcinoma (NPC). A better understanding of the mechanisms of radioresistance may generate new strategies to improve NPC patients' responses to therapy. This study was designed to investigate the effect of microRNA on the radiosensitivity of NPC cells. A microRNA microarray indicated that miR‐24 was downregulated in NPC cell lines and tissues. Furthermore, cell proliferation was suppressed and radiosensitivity increased when miR‐24 was ectopically expressed in NPC cells. Specificity protein 1 (SP1) was additionally verified as a direct functional target of miR‐24, which was found to be involved in cell viability as well as the radiosensitivity of NPC cells. In conclusion, the results of this study suggest that the miR‐24/SP1 pathway contributed to the reduction in radioresistance in human NPC and that it may thus represent a therapeutic target.
This study aimed to investigate the effect of microRNA (miR)‐24 on the radiosensitivity of NPC cells. The results of this study suggested that the identified miR‐24/Sp1 pathway contributed to the elucidation of the mechanisms of radiosensitivity in human NPC and that it may represent a potential therapeutic target.</abstract><cop>United States</cop><pub>John Wiley and Sons Inc</pub><pmid>26922862</pmid><doi>10.1002/cam4.660</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley Online Library Open Access; PubMed Central |
| subjects | Adult Aged Animals Cancer Biology Carcinoma Cell Line, Tumor Cell Survival - genetics Cell Survival - radiation effects Disease Models, Animal Female Gene Expression Profiling Gene Expression Regulation, Neoplastic Humans Male Mice MicroRNAs - chemistry MicroRNAs - genetics Middle Aged miR‐24 Nasopharyngeal Carcinoma Nasopharyngeal Neoplasms - genetics Nasopharyngeal Neoplasms - pathology Nasopharyngeal Neoplasms - radiotherapy Original Research Radiation Tolerance - genetics radiosensitivity RNA Interference RNA, Messenger - chemistry RNA, Messenger - genetics SP1 Sp1 Transcription Factor - genetics Xenograft Model Antitumor Assays Young Adult |
| title | MiR‐24 enhances radiosensitivity in nasopharyngeal carcinoma by targeting SP1 |
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