Sol-gel synthesis of thorn-like ZnO nanoparticles endorsing mechanical stirring effect and their antimicrobial activities: Potential role as nano-antibiotics
The effect of mechanical stirring on sol-gel synthesis of thorn-like ZnO nanoparticles (ZnO-NPs) and antimicrobial activities is successfully reported in this study. The in-house synthesized nanoparticles were characterized by XRD, SEM, TEM, FTIR, TGA, DSC and UV-visible spectroscopy. The X-Ray Diff...
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| Veröffentlicht in: | Scientific reports 2016-06, Vol.6 (1), p.27689-27689, Article 27689 |
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| creator | Khan, Mohd Farhan Ansari, Akhter H. Hameedullah, M. Ahmad, Ejaz Husain, Fohad Mabood Zia, Qamar Baig, Umair Zaheer, Mohd Rehan Alam, Mohammad Mezbaul Khan, Abu Mustafa AlOthman, Zeid A. Ahmad, Iqbal Ashraf, Ghulam Md Aliev, Gjumrakch |
| description | The effect of mechanical stirring on sol-gel synthesis of thorn-like ZnO nanoparticles (ZnO-NPs) and antimicrobial activities is successfully reported in this study. The in-house synthesized nanoparticles were characterized by XRD, SEM, TEM, FTIR, TGA, DSC and UV-visible spectroscopy. The X-Ray Diffraction analysis revealed the wurtzite crystal lattice for ZnO-NPs with no impurities present. The diametric measurements of the synthesized thorn-like ZnO-NPs (morphology assessed by SEM) were well accounted to be less than 50 nm with the help of TEM. Relative decrease in aspect ratio was observed on increasing the agitation speed. The UV-visible spectroscopy showed the absorption peaks of the ZnO-NPs existed in both UVA and UVB region. A hypsochromic shift in λmax was observed when stirring pace was increased from 500 rpm to 2000 rpm. The FTIR spectroscopy showed the absorption bands of the stretching modes of Zn-O between 500 cm
−1
to 525 cm
−1
. The Thermal analysis studies revealed better stability for ZnO-NPs prepared at 2000 rpm (ZnO-2000 rpm). TGA revealed the weight loss between two main temperatures ranges viz. around (90 °C–120 °C) and (240 °C–280 °C). Finally, the effect of ZnO-NPs prepared at different stirring conditions on the growth of Gram-positive (Bacillus subtilis), Gram-negative (Escherichia coli) bacteria and a fungi (Candida albicans) were examined; which showed good antibacterial as well as antifungal properties. These findings introduce a simple, inexpensive process to synthesize ZnO-NPs using conventional methods without the use of sophisticated equipments and its application as a potent nano-antibiotic. |
| doi_str_mv | 10.1038/srep27689 |
| format | Article |
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−1
to 525 cm
−1
. The Thermal analysis studies revealed better stability for ZnO-NPs prepared at 2000 rpm (ZnO-2000 rpm). TGA revealed the weight loss between two main temperatures ranges viz. around (90 °C–120 °C) and (240 °C–280 °C). Finally, the effect of ZnO-NPs prepared at different stirring conditions on the growth of Gram-positive (Bacillus subtilis), Gram-negative (Escherichia coli) bacteria and a fungi (Candida albicans) were examined; which showed good antibacterial as well as antifungal properties. These findings introduce a simple, inexpensive process to synthesize ZnO-NPs using conventional methods without the use of sophisticated equipments and its application as a potent nano-antibiotic.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep27689</identifier><identifier>PMID: 27349836</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/154/556 ; 631/1647/350/354 ; Absorption ; Anti-Infective Agents - chemistry ; Antibiotics ; Antimicrobial agents ; Bacillus subtilis - drug effects ; Calorimetry, Differential Scanning ; Candida albicans - drug effects ; E coli ; Electron microscopes ; Escherichia coli - drug effects ; Fourier transforms ; Hot Temperature ; Humanities and Social Sciences ; Humans ; Metal Nanoparticles - chemistry ; Microbial Sensitivity Tests ; Microscopy, Electron, Scanning ; Microscopy, Electron, Transmission ; multidisciplinary ; Nanoparticles ; Phase Transition ; Scanning electron microscopy ; Science ; Spectrophotometry, Ultraviolet ; Spectroscopy ; Spectroscopy, Fourier Transform Infrared ; Stress, Mechanical ; Thermal analysis ; Thermogravimetry ; Ultraviolet Rays ; X-Ray Diffraction ; Zinc Oxide - chemistry ; Zinc oxides</subject><ispartof>Scientific reports, 2016-06, Vol.6 (1), p.27689-27689, Article 27689</ispartof><rights>The Author(s) 2016</rights><rights>Copyright Nature Publishing Group Jun 2016</rights><rights>Copyright © 2016, Macmillan Publishers Limited 2016 Macmillan Publishers Limited</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-7f20577aae3f0c947f07c1d390f7f4e9a779f7ad52bb4c2f43c57bfb952cfbc03</citedby><cites>FETCH-LOGICAL-c438t-7f20577aae3f0c947f07c1d390f7f4e9a779f7ad52bb4c2f43c57bfb952cfbc03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4923881/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4923881/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27349836$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khan, Mohd Farhan</creatorcontrib><creatorcontrib>Ansari, Akhter H.</creatorcontrib><creatorcontrib>Hameedullah, M.</creatorcontrib><creatorcontrib>Ahmad, Ejaz</creatorcontrib><creatorcontrib>Husain, Fohad Mabood</creatorcontrib><creatorcontrib>Zia, Qamar</creatorcontrib><creatorcontrib>Baig, Umair</creatorcontrib><creatorcontrib>Zaheer, Mohd Rehan</creatorcontrib><creatorcontrib>Alam, Mohammad Mezbaul</creatorcontrib><creatorcontrib>Khan, Abu Mustafa</creatorcontrib><creatorcontrib>AlOthman, Zeid A.</creatorcontrib><creatorcontrib>Ahmad, Iqbal</creatorcontrib><creatorcontrib>Ashraf, Ghulam Md</creatorcontrib><creatorcontrib>Aliev, Gjumrakch</creatorcontrib><title>Sol-gel synthesis of thorn-like ZnO nanoparticles endorsing mechanical stirring effect and their antimicrobial activities: Potential role as nano-antibiotics</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>The effect of mechanical stirring on sol-gel synthesis of thorn-like ZnO nanoparticles (ZnO-NPs) and antimicrobial activities is successfully reported in this study. The in-house synthesized nanoparticles were characterized by XRD, SEM, TEM, FTIR, TGA, DSC and UV-visible spectroscopy. The X-Ray Diffraction analysis revealed the wurtzite crystal lattice for ZnO-NPs with no impurities present. The diametric measurements of the synthesized thorn-like ZnO-NPs (morphology assessed by SEM) were well accounted to be less than 50 nm with the help of TEM. Relative decrease in aspect ratio was observed on increasing the agitation speed. The UV-visible spectroscopy showed the absorption peaks of the ZnO-NPs existed in both UVA and UVB region. A hypsochromic shift in λmax was observed when stirring pace was increased from 500 rpm to 2000 rpm. The FTIR spectroscopy showed the absorption bands of the stretching modes of Zn-O between 500 cm
−1
to 525 cm
−1
. The Thermal analysis studies revealed better stability for ZnO-NPs prepared at 2000 rpm (ZnO-2000 rpm). TGA revealed the weight loss between two main temperatures ranges viz. around (90 °C–120 °C) and (240 °C–280 °C). Finally, the effect of ZnO-NPs prepared at different stirring conditions on the growth of Gram-positive (Bacillus subtilis), Gram-negative (Escherichia coli) bacteria and a fungi (Candida albicans) were examined; which showed good antibacterial as well as antifungal properties. These findings introduce a simple, inexpensive process to synthesize ZnO-NPs using conventional methods without the use of sophisticated equipments and its application as a potent nano-antibiotic.</description><subject>631/154/556</subject><subject>631/1647/350/354</subject><subject>Absorption</subject><subject>Anti-Infective Agents - chemistry</subject><subject>Antibiotics</subject><subject>Antimicrobial agents</subject><subject>Bacillus subtilis - drug effects</subject><subject>Calorimetry, Differential Scanning</subject><subject>Candida albicans - drug effects</subject><subject>E coli</subject><subject>Electron microscopes</subject><subject>Escherichia coli - drug effects</subject><subject>Fourier transforms</subject><subject>Hot Temperature</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Metal Nanoparticles - chemistry</subject><subject>Microbial Sensitivity Tests</subject><subject>Microscopy, Electron, Scanning</subject><subject>Microscopy, Electron, Transmission</subject><subject>multidisciplinary</subject><subject>Nanoparticles</subject><subject>Phase Transition</subject><subject>Scanning electron microscopy</subject><subject>Science</subject><subject>Spectrophotometry, Ultraviolet</subject><subject>Spectroscopy</subject><subject>Spectroscopy, Fourier Transform Infrared</subject><subject>Stress, Mechanical</subject><subject>Thermal analysis</subject><subject>Thermogravimetry</subject><subject>Ultraviolet Rays</subject><subject>X-Ray Diffraction</subject><subject>Zinc Oxide - 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chemistry</topic><topic>Zinc oxides</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khan, Mohd Farhan</creatorcontrib><creatorcontrib>Ansari, Akhter H.</creatorcontrib><creatorcontrib>Hameedullah, M.</creatorcontrib><creatorcontrib>Ahmad, Ejaz</creatorcontrib><creatorcontrib>Husain, Fohad Mabood</creatorcontrib><creatorcontrib>Zia, Qamar</creatorcontrib><creatorcontrib>Baig, Umair</creatorcontrib><creatorcontrib>Zaheer, Mohd Rehan</creatorcontrib><creatorcontrib>Alam, Mohammad Mezbaul</creatorcontrib><creatorcontrib>Khan, Abu Mustafa</creatorcontrib><creatorcontrib>AlOthman, Zeid A.</creatorcontrib><creatorcontrib>Ahmad, Iqbal</creatorcontrib><creatorcontrib>Ashraf, Ghulam Md</creatorcontrib><creatorcontrib>Aliev, Gjumrakch</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khan, Mohd Farhan</au><au>Ansari, Akhter H.</au><au>Hameedullah, M.</au><au>Ahmad, Ejaz</au><au>Husain, Fohad Mabood</au><au>Zia, Qamar</au><au>Baig, Umair</au><au>Zaheer, Mohd Rehan</au><au>Alam, Mohammad Mezbaul</au><au>Khan, Abu Mustafa</au><au>AlOthman, Zeid A.</au><au>Ahmad, Iqbal</au><au>Ashraf, Ghulam Md</au><au>Aliev, Gjumrakch</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sol-gel synthesis of thorn-like ZnO nanoparticles endorsing mechanical stirring effect and their antimicrobial activities: Potential role as nano-antibiotics</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2016-06-28</date><risdate>2016</risdate><volume>6</volume><issue>1</issue><spage>27689</spage><epage>27689</epage><pages>27689-27689</pages><artnum>27689</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>The effect of mechanical stirring on sol-gel synthesis of thorn-like ZnO nanoparticles (ZnO-NPs) and antimicrobial activities is successfully reported in this study. The in-house synthesized nanoparticles were characterized by XRD, SEM, TEM, FTIR, TGA, DSC and UV-visible spectroscopy. The X-Ray Diffraction analysis revealed the wurtzite crystal lattice for ZnO-NPs with no impurities present. The diametric measurements of the synthesized thorn-like ZnO-NPs (morphology assessed by SEM) were well accounted to be less than 50 nm with the help of TEM. Relative decrease in aspect ratio was observed on increasing the agitation speed. The UV-visible spectroscopy showed the absorption peaks of the ZnO-NPs existed in both UVA and UVB region. A hypsochromic shift in λmax was observed when stirring pace was increased from 500 rpm to 2000 rpm. The FTIR spectroscopy showed the absorption bands of the stretching modes of Zn-O between 500 cm
−1
to 525 cm
−1
. The Thermal analysis studies revealed better stability for ZnO-NPs prepared at 2000 rpm (ZnO-2000 rpm). TGA revealed the weight loss between two main temperatures ranges viz. around (90 °C–120 °C) and (240 °C–280 °C). Finally, the effect of ZnO-NPs prepared at different stirring conditions on the growth of Gram-positive (Bacillus subtilis), Gram-negative (Escherichia coli) bacteria and a fungi (Candida albicans) were examined; which showed good antibacterial as well as antifungal properties. These findings introduce a simple, inexpensive process to synthesize ZnO-NPs using conventional methods without the use of sophisticated equipments and its application as a potent nano-antibiotic.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>27349836</pmid><doi>10.1038/srep27689</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Springer Nature OA Free Journals; Nature Free; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | 631/154/556 631/1647/350/354 Absorption Anti-Infective Agents - chemistry Antibiotics Antimicrobial agents Bacillus subtilis - drug effects Calorimetry, Differential Scanning Candida albicans - drug effects E coli Electron microscopes Escherichia coli - drug effects Fourier transforms Hot Temperature Humanities and Social Sciences Humans Metal Nanoparticles - chemistry Microbial Sensitivity Tests Microscopy, Electron, Scanning Microscopy, Electron, Transmission multidisciplinary Nanoparticles Phase Transition Scanning electron microscopy Science Spectrophotometry, Ultraviolet Spectroscopy Spectroscopy, Fourier Transform Infrared Stress, Mechanical Thermal analysis Thermogravimetry Ultraviolet Rays X-Ray Diffraction Zinc Oxide - chemistry Zinc oxides |
| title | Sol-gel synthesis of thorn-like ZnO nanoparticles endorsing mechanical stirring effect and their antimicrobial activities: Potential role as nano-antibiotics |
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