Incorporation of Gallium-68 into the Crystal Structure of Prussian Blue to Form K68GaxFe1-x[Fe(CN)6] Nanoparticles: Toward a Novel Bimodal PET/MRI Imaging Agent
Similarity between the Ga 3+ ion and the Fe 3+ ion allows for partial replacement of Fe 3+ ions with Ga 3+ ions in the Fe(III) crystallographic positions in Prussian blue (PB) to form various solid solutions KGa x Fe 1-x [Fe(CN) 6 ] (0
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| Veröffentlicht in: | Dalton transactions : an international journal of inorganic chemistry 2016-05, Vol.45 (22), p.9174-9181 |
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| container_title | Dalton transactions : an international journal of inorganic chemistry |
| container_volume | 45 |
| creator | Kandanapitiye, Murthi S. Gott, Matthew D. Sharits, Andrew Jurisson, Silvia S. Woodward, Patrick M. Huang, Songping D. |
| description | Similarity between the Ga
3+
ion and the Fe
3+
ion allows for partial replacement of Fe
3+
ions with Ga
3+
ions in the Fe(III) crystallographic positions in Prussian blue (PB) to form various solid solutions KGa
x
Fe
1-x
[Fe(CN)
6
] (0 |
| doi_str_mv | 10.1039/c6dt00962j |
| format | Article |
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3+
ion and the Fe
3+
ion allows for partial replacement of Fe
3+
ions with Ga
3+
ions in the Fe(III) crystallographic positions in Prussian blue (PB) to form various solid solutions KGa
x
Fe
1-x
[Fe(CN)
6
] (0<x<1). Such solid solutions possess very high thermodynamic stability as expected from the parent PB structure. Consequently, a simple one-step
68
Ga-labeling method was developed for preparing a single-phase nanoparticulate bimodal PET/MRI imaging agent based on the PB structural platform. Unlike the typical
68
Ga-labelling reaction based on metal complexation, this novel chelator-free
68
Ga-labeling reaction was shown to be kinetically fast under the acidic conditions. The Ga
3+
ion does not hydrolyze, and affords the
68
Ga-labelled PB nanoparticles, which are easy to purify and have extremely high stability against radionuclidic leaching in aqueous solution.</description><identifier>ISSN: 1477-9226</identifier><identifier>EISSN: 1477-9234</identifier><identifier>DOI: 10.1039/c6dt00962j</identifier><identifier>PMID: 27169624</identifier><language>eng</language><ispartof>Dalton transactions : an international journal of inorganic chemistry, 2016-05, Vol.45 (22), p.9174-9181</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,778,782,883,27911,27912</link.rule.ids></links><search><creatorcontrib>Kandanapitiye, Murthi S.</creatorcontrib><creatorcontrib>Gott, Matthew D.</creatorcontrib><creatorcontrib>Sharits, Andrew</creatorcontrib><creatorcontrib>Jurisson, Silvia S.</creatorcontrib><creatorcontrib>Woodward, Patrick M.</creatorcontrib><creatorcontrib>Huang, Songping D.</creatorcontrib><title>Incorporation of Gallium-68 into the Crystal Structure of Prussian Blue to Form K68GaxFe1-x[Fe(CN)6] Nanoparticles: Toward a Novel Bimodal PET/MRI Imaging Agent</title><title>Dalton transactions : an international journal of inorganic chemistry</title><description>Similarity between the Ga
3+
ion and the Fe
3+
ion allows for partial replacement of Fe
3+
ions with Ga
3+
ions in the Fe(III) crystallographic positions in Prussian blue (PB) to form various solid solutions KGa
x
Fe
1-x
[Fe(CN)
6
] (0<x<1). Such solid solutions possess very high thermodynamic stability as expected from the parent PB structure. Consequently, a simple one-step
68
Ga-labeling method was developed for preparing a single-phase nanoparticulate bimodal PET/MRI imaging agent based on the PB structural platform. Unlike the typical
68
Ga-labelling reaction based on metal complexation, this novel chelator-free
68
Ga-labeling reaction was shown to be kinetically fast under the acidic conditions. The Ga
3+
ion does not hydrolyze, and affords the
68
Ga-labelled PB nanoparticles, which are easy to purify and have extremely high stability against radionuclidic leaching in aqueous solution.</description><issn>1477-9226</issn><issn>1477-9234</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNpVkEFLwzAAhYMobk4v_oIc9VCXpGm6eBC2ss3hnEPnSaSkabpltE1J07n9G3-qFUXw9B68j_fgAXCJ0Q1GPu9LljqEOCPbI9DFNAw9Tnx6_OcJ64Czut4iRAgKyCnokBCzlqdd8DkrpbGVscJpU0KTwanIc90UHhtAXToD3UbByB5qJ3L44mwjXWPVN7i0TV1rUcJR3ijYkhNjC_jABlOxnyjs7d8m6ipaXLN3uBClqYR1WuaqvoUr8yFsCgVcmJ3K4UgXJm3bl-NV__F5BmeFWOtyDYdrVbpzcJKJvFYXv9oDr5PxKrr35k_TWTScexUOmfNSJiRiWIUJZSmmMgmJTwYBR0mACCIMS-7TFJFsEPKESR5kJCM8ocKnfpBlgd8Ddz-9VZMUKpXttBV5XFldCHuIjdDx_6TUm3htdjFtD-aY-V_d1Hcy</recordid><startdate>20160531</startdate><enddate>20160531</enddate><creator>Kandanapitiye, Murthi S.</creator><creator>Gott, Matthew D.</creator><creator>Sharits, Andrew</creator><creator>Jurisson, Silvia S.</creator><creator>Woodward, Patrick M.</creator><creator>Huang, Songping D.</creator><scope>5PM</scope></search><sort><creationdate>20160531</creationdate><title>Incorporation of Gallium-68 into the Crystal Structure of Prussian Blue to Form K68GaxFe1-x[Fe(CN)6] Nanoparticles: Toward a Novel Bimodal PET/MRI Imaging Agent</title><author>Kandanapitiye, Murthi S. ; Gott, Matthew D. ; Sharits, Andrew ; Jurisson, Silvia S. ; Woodward, Patrick M. ; Huang, Songping D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p176t-d6ac061e7b46d14cb72328590b5020261c934d02f879b6c95f2f29b4a3435ff53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kandanapitiye, Murthi S.</creatorcontrib><creatorcontrib>Gott, Matthew D.</creatorcontrib><creatorcontrib>Sharits, Andrew</creatorcontrib><creatorcontrib>Jurisson, Silvia S.</creatorcontrib><creatorcontrib>Woodward, Patrick M.</creatorcontrib><creatorcontrib>Huang, Songping D.</creatorcontrib><collection>PubMed Central (Full Participant titles)</collection><jtitle>Dalton transactions : an international journal of inorganic chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kandanapitiye, Murthi S.</au><au>Gott, Matthew D.</au><au>Sharits, Andrew</au><au>Jurisson, Silvia S.</au><au>Woodward, Patrick M.</au><au>Huang, Songping D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Incorporation of Gallium-68 into the Crystal Structure of Prussian Blue to Form K68GaxFe1-x[Fe(CN)6] Nanoparticles: Toward a Novel Bimodal PET/MRI Imaging Agent</atitle><jtitle>Dalton transactions : an international journal of inorganic chemistry</jtitle><date>2016-05-31</date><risdate>2016</risdate><volume>45</volume><issue>22</issue><spage>9174</spage><epage>9181</epage><pages>9174-9181</pages><issn>1477-9226</issn><eissn>1477-9234</eissn><abstract>Similarity between the Ga
3+
ion and the Fe
3+
ion allows for partial replacement of Fe
3+
ions with Ga
3+
ions in the Fe(III) crystallographic positions in Prussian blue (PB) to form various solid solutions KGa
x
Fe
1-x
[Fe(CN)
6
] (0<x<1). Such solid solutions possess very high thermodynamic stability as expected from the parent PB structure. Consequently, a simple one-step
68
Ga-labeling method was developed for preparing a single-phase nanoparticulate bimodal PET/MRI imaging agent based on the PB structural platform. Unlike the typical
68
Ga-labelling reaction based on metal complexation, this novel chelator-free
68
Ga-labeling reaction was shown to be kinetically fast under the acidic conditions. The Ga
3+
ion does not hydrolyze, and affords the
68
Ga-labelled PB nanoparticles, which are easy to purify and have extremely high stability against radionuclidic leaching in aqueous solution.</abstract><pmid>27169624</pmid><doi>10.1039/c6dt00962j</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| title | Incorporation of Gallium-68 into the Crystal Structure of Prussian Blue to Form K68GaxFe1-x[Fe(CN)6] Nanoparticles: Toward a Novel Bimodal PET/MRI Imaging Agent |
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