MicroRNA-140-5p and SMURF1 regulate pulmonary arterial hypertension

Loss of the growth-suppressive effects of bone morphogenetic protein (BMP) signaling has been demonstrated to promote pulmonary arterial endothelial cell dysfunction and induce pulmonary arterial smooth muscle cell (PASMC) proliferation, leading to the development of pulmonary arterial hypertension...

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Veröffentlicht in:	The Journal of clinical investigation 2016-07, Vol.126 (7), p.2495-2508
Hauptverfasser:	Rothman, Alexander M K, Arnold, Nadine D, Pickworth, Josephine A, Iremonger, James, Ciuclan, Loredana, Allen, Robert M H, Guth-Gundel, Sabine, Southwood, Mark, Morrell, Nicholas W, Thomas, Matthew, Francis, Sheila E, Rowlands, David J, Lawrie, Allan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Analysis Animals Apoptosis Binding sites Biomedical research Care and treatment Drug therapy Experiments Genetic aspects Humans Hypertension Hypertension, Pulmonary - metabolism Hypoxia Male Medical research Mice Mice, Inbred C57BL Mice, Transgenic MicroRNA MicroRNAs MicroRNAs - metabolism Middle Aged Mutation Pathology Phenotype Proteins Pulmonary arteries Pulmonary Artery - pathology Pulmonary hypertension Rats Rats, Sprague-Dawley Rats, Wistar Rodents Signal Transduction Smooth muscle Studies Ubiquitin-Protein Ligases - metabolism Veins & arteries
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