Matrix metalloproteinase-9-dependent mechanisms of reduced contractility and increased stiffness in the aging heart

Purpose Matrix metalloproteinases (MMPs) collectively degrade all extracellular matrix (ECM) proteins. Of the MMPs, MMP‐9 has the strongest link to the development of cardiac dysfunction. Aging associates with increased MMP‐9 expression in the left ventricle (LV) and reduced cardiac function. We inv...

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Veröffentlicht in:	Proteomics. Clinical applications 2016-01, Vol.10 (1), p.92-107
Hauptverfasser:	Padmanabhan Iyer, Rugmani, Chiao, Ying Ann, Flynn, Elizabeth R., Hakala, Kevin, Cates, Courtney A., Weintraub, Susan T., de Castro Brás, Lisandra E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aging Aging - genetics Aging - metabolism Aging - pathology Animals Cardiac stiffness Cell adhesion & migration EMILIN Female Left ventricle Male Matrix metalloproteinase Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase 9 - metabolism Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Mice Mice, Mutant Strains MMP-9 Muscle Proteins - genetics Muscle Proteins - metabolism Myocardial Contraction Myocardium - metabolism Myocardium - pathology Proteins Rodents Talin
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