Photodegradation of retinal bisretinoids in mouse models and implications for macular degeneration

Adducts of retinaldehyde (bisretinoids) form nonenzymatically in photoreceptor cells and accumulate in retinal pigment epithelial (RPE) cells as lipofuscin; these fluorophores are implicated in the pathogenesis of inherited and age-related macular degeneration (AMD). Here we demonstrate that bisreti...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2016-06, Vol.113 (25), p.6904-6909
Hauptverfasser:	Ueda, Keiko, Zhao, Jin, Kim, Hye Jin, Sparrow, Janet R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences Darkness Light Macular Degeneration - etiology Mice Mice, Inbred C57BL Oxidation-Reduction Retina - metabolism Retina - radiation effects Retinoids - metabolism
Online-Zugang:	Volltext
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