Transplantation of iPSC-derived TM cells rescues glaucoma phenotypes in vivo

Glaucoma is a common cause of vision loss or blindness and reduction of intraocular pressure (IOP) has been proven beneficial in a large fraction of glaucoma patients. The IOP is maintained by the trabecular meshwork (TM) and the elevation of IOP in open-angle glaucoma is associated with dysfunction...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2016-06, Vol.113 (25), p.E3492-E3500
Hauptverfasser:	Zhu, Wei, Gramlich, Oliver W., Laboissonniere, Lauren, Jain, Ankur, Sheffield, Val C., Trimarchi, Jeffrey M., Tucker, Budd A., Kuehn, Markus H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences Blindness Cytoskeletal Proteins - genetics Disease Models, Animal Eye Proteins - genetics Genotype & phenotype Glaucoma Glaucoma - pathology Glaucoma - physiopathology Glaucoma - therapy Glycoproteins - genetics Humans Intraocular Pressure Mice Mice, Transgenic Mutation PNAS Plus Rodents Stem Cell Transplantation Stem cells Trabecular Meshwork - pathology
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