A de novo silencer causes elimination of MITF-M expression and profound hearing loss in pigs

Genesis of novel gene regulatory modules is largely responsible for morphological and functional evolution. De novo generation of novel cis-regulatory elements (CREs) is much rarer than genomic events that alter existing CREs such as transposition, promoter switching or co-option. Only one case of d...

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Veröffentlicht in:	BMC biology 2016-06, Vol.14 (1), p.52-52, Article 52
Hauptverfasser:	Chen, Lei, Guo, Weiwei, Ren, Lili, Yang, Mingyao, Zhao, Yaofeng, Guo, Zongyi, Yi, Haijin, Li, Mingzhou, Hu, Yiqing, Long, Xi, Sun, Boyuan, Li, Jinxiu, Zhai, Suoqiang, Zhang, Tinghuan, Tian, Shilin, Meng, Qingyong, Yu, Ning, Zhu, Dan, Tang, Guoqing, Tang, Qianzi, Ren, Liming, Liu, Ke, Zhang, Shihua, Che, Tiandong, Yu, Zhengquan, Wu, Nan, Jing, Lan, Zhang, Ran, Cong, Tao, Chen, Siqing, Zhao, Yiqiang, Zhang, Yue, Bai, Xiaoqing, Guo, Ying, Zhao, Lidong, Zhang, Fengming, Zhao, Hui, Zhang, Liang, Hou, Zhaohui, Zhao, Jiugang, Li, Jianan, Zhang, Lijuan, Sun, Wei, Zou, Xiangang, Wang, Tao, Ge, Liangpeng, Liu, Zuohua, Hu, Xiaoxiang, Wang, Jingyong, Yang, Shiming, Li, Ning
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Base Sequence Chromosome Mapping Cochlea - pathology Cochlea - physiopathology Disease Models, Animal Electrophysiological Phenomena Gene expression Gene Expression Regulation Genetic Testing Genetic transcription Genome-Wide Association Study Health aspects Hearing loss Hearing Loss - genetics Hearing Loss - physiopathology Hogs Microphthalmia-Associated Transcription Factor - genetics Microphthalmia-Associated Transcription Factor - metabolism Mutation - genetics Phenotype Promoter Regions, Genetic Protein Isoforms - genetics Silencer Elements, Transcriptional - genetics Single nucleotide polymorphisms Sus scrofa - genetics Transcription, Genetic
Online-Zugang:	Volltext
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