Time-to-Progression of NSCLC from Early to Advanced Stages: An Analysis of data from SEER Registry and a Single Institute
The average time required for cancers to progress through stages can be reflected in the average age of the patients diagnosed at each stage of disease. To estimate the time it takes for non-small-cell lung cancer (NSCLC) to progress through different tumor, node and metastasis (TNM) stages and size...
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| Veröffentlicht in: | Scientific reports 2016-06, Vol.6 (1), p.28477-28477, Article 28477 |
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| creator | Yuan, Ping Cao, Jin Lin Rustam, Azmat Zhang, Chong Yuan, Xiao Shuai Bao, Fei Chao Lv, Wang Hu, Jian |
| description | The average time required for cancers to progress through stages can be reflected in the average age of the patients diagnosed at each stage of disease. To estimate the time it takes for non-small-cell lung cancer (NSCLC) to progress through different tumor, node and metastasis (TNM) stages and sizes, we compared the mean adjusted age of 45904 NSCLC patients with different stages and tumor sizes from Surveillance, Epidemiology and End Results (SEER) cancer registry database and our institute. Multiple-linear-regression models for age were generated adjusting for various factors. Caucasian, African-American and Asian patients with stage IA cancers were on average 0.8, 1.0 and 1.38 adjusted years younger, respectively, than those with stage IIIB cancers (p |
| doi_str_mv | 10.1038/srep28477 |
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To estimate the time it takes for non-small-cell lung cancer (NSCLC) to progress through different tumor, node and metastasis (TNM) stages and sizes, we compared the mean adjusted age of 45904 NSCLC patients with different stages and tumor sizes from Surveillance, Epidemiology and End Results (SEER) cancer registry database and our institute. Multiple-linear-regression models for age were generated adjusting for various factors. Caucasian, African-American and Asian patients with stage IA cancers were on average 0.8, 1.0 and 1.38 adjusted years younger, respectively, than those with stage IIIB cancers (p < 0.001). And these with T1a cancers were on average 0.84, 0.92 and 1.21 adjusted years younger, respectively, than patients with T3 cancers (p < 0.001). Patients with tumors measuring larger than 8 cm in diameter were on average 0.85 adjusted years older than these with tumors smaller than 1 cm (p < 0.001), with Caucasian demonstrating the shortest age span (0.79 years, P < 0.001). In conclusion, the time-to-progression of NSCLC from early to advanced stages varied among ethnicities, Caucasian patients demonstrating a more rapid progression nature of tumor than their African-American and Asian counterparts.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep28477</identifier><identifier>PMID: 27346236</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/4028/67/1612/1350 ; 692/699/67/1612/1350 ; Adult ; African Americans ; Aged ; Aged, 80 and over ; Asian people ; Black or African American ; Carcinoma, Non-Small-Cell Lung - pathology ; Disease Progression ; Epidemiology ; Ethnicity ; Female ; Humanities and Social Sciences ; Humans ; Lung cancer ; Lung Neoplasms - pathology ; Male ; Males ; Medical screening ; Middle Aged ; multidisciplinary ; Neoplasm Staging - methods ; Patients ; Registries ; Regression analysis ; Science ; Science (multidisciplinary) ; SEER Program ; Surveillance ; Tumors ; White People</subject><ispartof>Scientific reports, 2016-06, Vol.6 (1), p.28477-28477, Article 28477</ispartof><rights>The Author(s) 2016</rights><rights>Copyright Nature Publishing Group Jun 2016</rights><rights>Copyright © 2016, Macmillan Publishers Limited 2016 Macmillan Publishers Limited</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-d957e1ff9c1df58409053f4e8cf15bc446a715a8469ece994b34f1485a574f193</citedby><cites>FETCH-LOGICAL-c438t-d957e1ff9c1df58409053f4e8cf15bc446a715a8469ece994b34f1485a574f193</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4921917/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4921917/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,41096,42165,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27346236$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yuan, Ping</creatorcontrib><creatorcontrib>Cao, Jin Lin</creatorcontrib><creatorcontrib>Rustam, Azmat</creatorcontrib><creatorcontrib>Zhang, Chong</creatorcontrib><creatorcontrib>Yuan, Xiao Shuai</creatorcontrib><creatorcontrib>Bao, Fei Chao</creatorcontrib><creatorcontrib>Lv, Wang</creatorcontrib><creatorcontrib>Hu, Jian</creatorcontrib><title>Time-to-Progression of NSCLC from Early to Advanced Stages: An Analysis of data from SEER Registry and a Single Institute</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>The average time required for cancers to progress through stages can be reflected in the average age of the patients diagnosed at each stage of disease. To estimate the time it takes for non-small-cell lung cancer (NSCLC) to progress through different tumor, node and metastasis (TNM) stages and sizes, we compared the mean adjusted age of 45904 NSCLC patients with different stages and tumor sizes from Surveillance, Epidemiology and End Results (SEER) cancer registry database and our institute. Multiple-linear-regression models for age were generated adjusting for various factors. Caucasian, African-American and Asian patients with stage IA cancers were on average 0.8, 1.0 and 1.38 adjusted years younger, respectively, than those with stage IIIB cancers (p < 0.001). And these with T1a cancers were on average 0.84, 0.92 and 1.21 adjusted years younger, respectively, than patients with T3 cancers (p < 0.001). Patients with tumors measuring larger than 8 cm in diameter were on average 0.85 adjusted years older than these with tumors smaller than 1 cm (p < 0.001), with Caucasian demonstrating the shortest age span (0.79 years, P < 0.001). 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yuan, Ping</au><au>Cao, Jin Lin</au><au>Rustam, Azmat</au><au>Zhang, Chong</au><au>Yuan, Xiao Shuai</au><au>Bao, Fei Chao</au><au>Lv, Wang</au><au>Hu, Jian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Time-to-Progression of NSCLC from Early to Advanced Stages: An Analysis of data from SEER Registry and a Single Institute</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2016-06-27</date><risdate>2016</risdate><volume>6</volume><issue>1</issue><spage>28477</spage><epage>28477</epage><pages>28477-28477</pages><artnum>28477</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>The average time required for cancers to progress through stages can be reflected in the average age of the patients diagnosed at each stage of disease. To estimate the time it takes for non-small-cell lung cancer (NSCLC) to progress through different tumor, node and metastasis (TNM) stages and sizes, we compared the mean adjusted age of 45904 NSCLC patients with different stages and tumor sizes from Surveillance, Epidemiology and End Results (SEER) cancer registry database and our institute. Multiple-linear-regression models for age were generated adjusting for various factors. Caucasian, African-American and Asian patients with stage IA cancers were on average 0.8, 1.0 and 1.38 adjusted years younger, respectively, than those with stage IIIB cancers (p < 0.001). And these with T1a cancers were on average 0.84, 0.92 and 1.21 adjusted years younger, respectively, than patients with T3 cancers (p < 0.001). Patients with tumors measuring larger than 8 cm in diameter were on average 0.85 adjusted years older than these with tumors smaller than 1 cm (p < 0.001), with Caucasian demonstrating the shortest age span (0.79 years, P < 0.001). In conclusion, the time-to-progression of NSCLC from early to advanced stages varied among ethnicities, Caucasian patients demonstrating a more rapid progression nature of tumor than their African-American and Asian counterparts.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>27346236</pmid><doi>10.1038/srep28477</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 692/4028/67/1612/1350 692/699/67/1612/1350 Adult African Americans Aged Aged, 80 and over Asian people Black or African American Carcinoma, Non-Small-Cell Lung - pathology Disease Progression Epidemiology Ethnicity Female Humanities and Social Sciences Humans Lung cancer Lung Neoplasms - pathology Male Males Medical screening Middle Aged multidisciplinary Neoplasm Staging - methods Patients Registries Regression analysis Science Science (multidisciplinary) SEER Program Surveillance Tumors White People |
| title | Time-to-Progression of NSCLC from Early to Advanced Stages: An Analysis of data from SEER Registry and a Single Institute |
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