Dexamethasone in the management of symptoms due to herniated lumbar disc
One hundred consecutive patients with radicular pain due to myelographically proven herniated lumbar intervertebral discs were treated with initially high but tapering doses of intramuscular dexamethasone for seven days. All patients had reflief of pain within 24-48 hours. Bed rest was eliminated as...
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| Veröffentlicht in: | Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 1975-12, Vol.38 (12), p.1211-1217 |
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| container_issue | 12 |
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| container_title | Journal of neurology, neurosurgery and psychiatry |
| container_volume | 38 |
| creator | Green, L N |
| description | One hundred consecutive patients with radicular pain due to myelographically proven herniated lumbar intervertebral discs were treated with initially high but tapering doses of intramuscular dexamethasone for seven days. All patients had reflief of pain within 24-48 hours. Bed rest was eliminated as a significant factor in the improvement. Nine patients required surgery at the end of the hospital treatment period. Another 11 required surgery during the follow-up of 15 months. Review of work status and recurrent pain during the follow-up indicates that the non-surgically treated patients in this series fared better. It is concluded that nerve root inflammation is the immediate cause of radicular symptoms in case of ruptured lumbar disc and that treatment with dexamethasone gives prompt relief of pain and may avoid the need for surgery in most cases. |
| doi_str_mv | 10.1136/jnnp.38.12.1211 |
| format | Article |
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All patients had reflief of pain within 24-48 hours. Bed rest was eliminated as a significant factor in the improvement. Nine patients required surgery at the end of the hospital treatment period. Another 11 required surgery during the follow-up of 15 months. Review of work status and recurrent pain during the follow-up indicates that the non-surgically treated patients in this series fared better. It is concluded that nerve root inflammation is the immediate cause of radicular symptoms in case of ruptured lumbar disc and that treatment with dexamethasone gives prompt relief of pain and may avoid the need for surgery in most cases.</description><identifier>ISSN: 0022-3050</identifier><identifier>EISSN: 1468-330X</identifier><identifier>DOI: 10.1136/jnnp.38.12.1211</identifier><identifier>PMID: 1219086</identifier><identifier>CODEN: JNNPAU</identifier><language>eng</language><publisher>England: BMJ Publishing Group Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Dexamethasone - administration & dosage ; Dexamethasone - therapeutic use ; Humans ; Injections, Intramuscular ; Intervertebral Disc Displacement - drug therapy ; Intervertebral Disc Displacement - rehabilitation ; Intervertebral Disc Displacement - surgery ; Lumbar Vertebrae ; Male ; Middle Aged ; Pain</subject><ispartof>Journal of neurology, neurosurgery and psychiatry, 1975-12, Vol.38 (12), p.1211-1217</ispartof><rights>Copyright BMJ Publishing Group LTD Dec 1975</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b488t-a57d2e1465c6b3d635d7703363d84161031d7277afdc1452f8b6bb41959215193</citedby><cites>FETCH-LOGICAL-b488t-a57d2e1465c6b3d635d7703363d84161031d7277afdc1452f8b6bb41959215193</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC492190/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC492190/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1219086$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Green, L N</creatorcontrib><title>Dexamethasone in the management of symptoms due to herniated lumbar disc</title><title>Journal of neurology, neurosurgery and psychiatry</title><addtitle>J Neurol Neurosurg Psychiatry</addtitle><description>One hundred consecutive patients with radicular pain due to myelographically proven herniated lumbar intervertebral discs were treated with initially high but tapering doses of intramuscular dexamethasone for seven days. 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It is concluded that nerve root inflammation is the immediate cause of radicular symptoms in case of ruptured lumbar disc and that treatment with dexamethasone gives prompt relief of pain and may avoid the need for surgery in most cases.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Dexamethasone - administration & dosage</subject><subject>Dexamethasone - therapeutic use</subject><subject>Humans</subject><subject>Injections, Intramuscular</subject><subject>Intervertebral Disc Displacement - drug therapy</subject><subject>Intervertebral Disc Displacement - rehabilitation</subject><subject>Intervertebral Disc Displacement - surgery</subject><subject>Lumbar Vertebrae</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pain</subject><issn>0022-3050</issn><issn>1468-330X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1975</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkcFrFDEYxYModa2ePQkBwYMw23yTmSRz8FC22lqKQqniLWQmme6sk2RNMtL-92aYUlsvhkAO7_fle4-H0GsgawDKjnbO7ddUrKHMF-AJWkHFREEp-fEUrQgpy4KSmjxHL2LckfmI5gAdZLYhgq3Q2Ym5UdakrYreGTw4nLYGW-XUtbHGJex7HG_tPnkbsZ4MTh5vTXCDSkbjcbKtClgPsXuJnvVqjObV3XuIvn36eLU5Ky6-nn7eHF8UbSVEKlTNdWmyx7pjLdWM1ppzQimjWlTAgFDQvORc9bqDqi570bK2raCpmxJqaOgh-rD8u59aa3SXPQY1yn0YrAq30qtBPlbcsJXX_resmjlznn93Nx_8r8nEJG12b8ZROeOnKAUFTkCwDL79B9z5KbicTQLnpSCkZrOdo4Xqgo8xmP7eCRA5NyTnhiQVEko5N5Qn3jwM8JdfKsl6sehDTObmXlbhp2Sc8lp--b6Rl6f0hPDzczkHer_wrd39d_kf0fmolg</recordid><startdate>19751201</startdate><enddate>19751201</enddate><creator>Green, L N</creator><general>BMJ Publishing Group Ltd</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19751201</creationdate><title>Dexamethasone in the management of symptoms due to herniated lumbar disc</title><author>Green, L N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b488t-a57d2e1465c6b3d635d7703363d84161031d7277afdc1452f8b6bb41959215193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1975</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Dexamethasone - administration & dosage</topic><topic>Dexamethasone - therapeutic use</topic><topic>Humans</topic><topic>Injections, Intramuscular</topic><topic>Intervertebral Disc Displacement - drug therapy</topic><topic>Intervertebral Disc Displacement - rehabilitation</topic><topic>Intervertebral Disc Displacement - surgery</topic><topic>Lumbar Vertebrae</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pain</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Green, L N</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of neurology, neurosurgery and psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Green, L N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dexamethasone in the management of symptoms due to herniated lumbar disc</atitle><jtitle>Journal of neurology, neurosurgery and psychiatry</jtitle><addtitle>J Neurol Neurosurg Psychiatry</addtitle><date>1975-12-01</date><risdate>1975</risdate><volume>38</volume><issue>12</issue><spage>1211</spage><epage>1217</epage><pages>1211-1217</pages><issn>0022-3050</issn><eissn>1468-330X</eissn><coden>JNNPAU</coden><abstract>One hundred consecutive patients with radicular pain due to myelographically proven herniated lumbar intervertebral discs were treated with initially high but tapering doses of intramuscular dexamethasone for seven days. All patients had reflief of pain within 24-48 hours. Bed rest was eliminated as a significant factor in the improvement. Nine patients required surgery at the end of the hospital treatment period. Another 11 required surgery during the follow-up of 15 months. Review of work status and recurrent pain during the follow-up indicates that the non-surgically treated patients in this series fared better. It is concluded that nerve root inflammation is the immediate cause of radicular symptoms in case of ruptured lumbar disc and that treatment with dexamethasone gives prompt relief of pain and may avoid the need for surgery in most cases.</abstract><cop>England</cop><pub>BMJ Publishing Group Ltd</pub><pmid>1219086</pmid><doi>10.1136/jnnp.38.12.1211</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0022-3050 |
| ispartof | Journal of neurology, neurosurgery and psychiatry, 1975-12, Vol.38 (12), p.1211-1217 |
| issn | 0022-3050 1468-330X |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adolescent Adult Aged Dexamethasone - administration & dosage Dexamethasone - therapeutic use Humans Injections, Intramuscular Intervertebral Disc Displacement - drug therapy Intervertebral Disc Displacement - rehabilitation Intervertebral Disc Displacement - surgery Lumbar Vertebrae Male Middle Aged Pain |
| title | Dexamethasone in the management of symptoms due to herniated lumbar disc |
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