Phylogeographical analysis of the dominant multidrug-resistant H58 clade of Salmonella Typhi identifies inter- and intracontinental transmission events

Vanessa Wong and colleagues report whole-genome sequencing of 1,832 Salmonella enterica serovar Typhi isolates from 63 endemic countries. They identify mutations that define the multidrug resistant (MDR) H58 lineage and report numerous inter- and intracontinental transmissions of this lineage as wel...

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Veröffentlicht in:	Nature genetics 2015-06, Vol.47 (6), p.632-639
Hauptverfasser:	Wong, Vanessa K, Baker, Stephen, Pickard, Derek J, Parkhill, Julian, Page, Andrew J, Feasey, Nicholas A, Kingsley, Robert A, Thomson, Nicholas R, Keane, Jacqueline A, Weill, François-Xavier, Edwards, David J, Hawkey, Jane, Harris, Simon R, Mather, Alison E, Cain, Amy K, Hadfield, James, Hart, Peter J, Thieu, Nga Tran Vu, Klemm, Elizabeth J, Glinos, Dafni A, Breiman, Robert F, Watson, Conall H, Kariuki, Samuel, Gordon, Melita A, Heyderman, Robert S, Okoro, Chinyere, Jacobs, Jan, Lunguya, Octavie, Edmunds, W John, Msefula, Chisomo, Chabalgoity, Jose A, Kama, Mike, Jenkins, Kylie, Dutta, Shanta, Marks, Florian, Campos, Josefina, Thompson, Corinne, Obaro, Stephen, MacLennan, Calman A, Dolecek, Christiane, Keddy, Karen H, Smith, Anthony M, Parry, Christopher M, Karkey, Abhilasha, Mulholland, E Kim, Campbell, James I, Dongol, Sabina, Basnyat, Buddha, Dufour, Muriel, Bandaranayake, Don, Naseri, Take Toleafoa, Singh, Shalini Pravin, Hatta, Mochammad, Newton, Paul, Onsare, Robert S, Isaia, Lupeoletalalei, Dance, David, Davong, Viengmon, Thwaites, Guy, Wijedoru, Lalith, Crump, John A, De Pinna, Elizabeth, Nair, Satheesh, Nilles, Eric J, Thanh, Duy Pham, Turner, Paul, Soeng, Sona, Valcanis, Mary, Powling, Joan, Dimovski, Karolina, Hogg, Geoff, Farrar, Jeremy, Holt, Kathryn E, Dougan, Gordon
Format:	Artikel
Sprache:	eng
Schlagworte:	45/23 631/326/1320 Acquisitions & mergers Agriculture Analysis Animal Genetics and Genomics Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Antibiotics Australia Bacterial genetics Bacteriology Biomedicine Cancer Research Councils Data collection Diseases DNA sequencing Drug resistance Drug resistance in microorganisms Drug Resistance, Multiple, Bacterial Epidemics Fiji Gene Function Genetic aspects Genome, Bacterial Genomes Genomics Global health Haplotypes Health Health aspects Health risks Human Genetics Humans Identification and classification India Infectious diseases Kenya Life Sciences Malawi Medical research Medical schools Microbial drug resistance Microbiology and Parasitology Molecular Sequence Data Mutation Phylogenetics Phylogeny Phylogeography Plasmids Population Population structure Quinolines - pharmacology Quinolines - therapeutic use Salmonella Salmonella typhi - genetics Salmonella typhosa Sequence Analysis, DNA South Africa Southeast Asia Typhoid Typhoid fever Typhoid Fever - drug therapy Typhoid Fever - microbiology Typhoid Fever - transmission United Kingdom Vietnam Virulence (Microbiology) World health
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