Innervation regulates synaptic ribbons in lateral line mechanosensory hair cells

Failure to form proper synapses in mechanosensory hair cells, the sensory cells responsible for hearing and balance, leads to deafness and balance disorders. Ribbons are electron-dense structures that tether synaptic vesicles to the presynaptic zone of mechanosensory hair cells where they are juxtap...

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Veröffentlicht in:	Journal of cell science 2016-06, Vol.129 (11), p.2250-2260
Hauptverfasser:	Suli, Arminda, Pujol, Remy, Cunningham, Dale E, Hailey, Dale W, Prendergast, Andrew, Rubel, Edwin W, Raible, David W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Danio rerio Hair Cells, Auditory, Inner - metabolism Hair Cells, Auditory, Inner - ultrastructure Lateral Line System - innervation Lateral Line System - metabolism Lateral Line System - ultrastructure Mechanotransduction, Cellular Membranes - metabolism Mutation - genetics Synapses - metabolism Synapses - ultrastructure Synaptic Vesicles - metabolism Synaptic Vesicles - ultrastructure Zebrafish
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