Factor XI as a Therapeutic Target

Factor XIa is a plasma serine protease that contributes to thrombin generation primarily through proteolytic activation of factor IX. Traditionally considered part of the intrinsic pathway of coagulation, several lines of evidence now suggest that factor XIa serves as an interface between the vitami...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2016-07, Vol.36 (7), p.1316-1322
Hauptverfasser:	Gailani, David, Gruber, Andras
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticoagulants - adverse effects Anticoagulants - therapeutic use Blood Coagulation - drug effects Disease Models, Animal Drug Design Factor XIa - antagonists & inhibitors Factor XIa - metabolism Fibrinolytic Agents - adverse effects Fibrinolytic Agents - therapeutic use Hemorrhage - chemically induced Humans Molecular Targeted Therapy Risk Factors Thrombosis - blood Thrombosis - prevention & control Treatment Outcome
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