Medicinal chemistry of cannabinoids
The endocannabinoid system comprises the two well characterized Gi/o‐protein coupled receptors (cannabinoid receptor 1 (CB1) and CB2), their endogenous lipid ligands, and the enzymes involved in their biosynthesis and biotransformation. Drug discovery efforts relating to the endocannabinoid system h...
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| Veröffentlicht in: | Clinical pharmacology and therapeutics 2015-06, Vol.97 (6), p.553-558 |
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| container_title | Clinical pharmacology and therapeutics |
| container_volume | 97 |
| creator | Vemuri, V Kiran Makriyannis, A |
| description | The endocannabinoid system comprises the two well characterized Gi/o‐protein coupled receptors (cannabinoid receptor 1 (CB1) and CB2), their endogenous lipid ligands, and the enzymes involved in their biosynthesis and biotransformation. Drug discovery efforts relating to the endocannabinoid system have been focused mainly on the two cannabinoid receptors and the two endocannabinoid deactivating enzymes fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MGL). This review provides an overview of cannabinergic agents used in drug research and those being explored clinically. |
| doi_str_mv | 10.1002/cpt.115 |
| format | Article |
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Drug discovery efforts relating to the endocannabinoid system have been focused mainly on the two cannabinoid receptors and the two endocannabinoid deactivating enzymes fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MGL). 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| ispartof | Clinical pharmacology and therapeutics, 2015-06, Vol.97 (6), p.553-558 |
| issn | 0009-9236 1532-6535 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Amidohydrolases - antagonists & inhibitors Cannabinoids - therapeutic use Chemistry, Pharmaceutical Drug Discovery Humans Monoacylglycerol Lipases - antagonists & inhibitors Receptor, Cannabinoid, CB1 - agonists Receptor, Cannabinoid, CB1 - antagonists & inhibitors Receptor, Cannabinoid, CB1 - physiology Receptor, Cannabinoid, CB2 - agonists Receptor, Cannabinoid, CB2 - physiology Translation |
| title | Medicinal chemistry of cannabinoids |
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