Structural basis for autoinhibition and its relief of MOB1 in the Hippo pathway

MOB1 protein is a key regulator of large tumor suppressor 1/2 (LATS1/2) kinases in the Hippo pathway. MOB1 is present in an autoinhibited form and is activated by MST1/2-mediated phosphorylation, although the precise mechanisms responsible for autoinhibition and activation are unknown due to lack of...

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Veröffentlicht in:	Scientific reports 2016-06, Vol.6 (1), p.28488-28488, Article 28488
Hauptverfasser:	Kim, Sun-Yong, Tachioka, Yuka, Mori, Tomoyuki, Hakoshima, Toshio
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45/612/1243 631/535/1266 82 82/80 82/83 96 Adaptor Proteins, Signal Transducing - chemistry Adaptor Proteins, Signal Transducing - metabolism Animals Cell growth Escherichia coli - metabolism Humanities and Social Sciences Kinases Mice multidisciplinary Phosphoproteins - chemistry Phosphoproteins - metabolism Phosphorylation Phosphorylation - physiology Protein Binding - physiology Protein Conformation, alpha-Helical Protein Conformation, beta-Strand Protein Domains Protein Serine-Threonine Kinases - chemistry Protein Serine-Threonine Kinases - metabolism Proteins Science Signal Transduction - physiology
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